Quality of Life Research

, Volume 19, Issue 9, pp 1295–1302

HIV and COPD: impact of risk behaviors and diseases on quality of life

  • M. Bradley Drummond
  • Gregory D. Kirk
  • Meredith C. McCormack
  • Mariah M. Marshall
  • Erin P. Ricketts
  • Shruti H. Mehta
  • Robert A. Wise
  • Christian A. Merlo
Article

DOI: 10.1007/s11136-010-9701-x

Cite this article as:
Drummond, M.B., Kirk, G.D., McCormack, M.C. et al. Qual Life Res (2010) 19: 1295. doi:10.1007/s11136-010-9701-x
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Abstract

Purpose

Smoking worsens quality of life among HIV-infected individuals, but it remains unclear if this association is related simply to smoking or to chronic obstructive pulmonary disease (COPD), the end-organ disease caused by smoking.

Methods

Using cross-sectional data from the AIDS Linked to the Intravenous Experience study, we determined the independent effects of smoking, HIV and COPD assessed using the Medical Outcome Studies-HIV questionnaire.

Results

Of 973 participants, 287 (29.5%) were HIV infected and 151 (15.5%) had spirometry-defined obstruction. Eight hundred and thirty-four (85.7%) were current smokers with 23.3 mean pack-years history. HIV infection was independently associated with reduced physical and mental health. COPD was associated with a trend toward worse physical health (−1.48 units; 95%CI −3.33 to 0.38; p = 0.12) and was independently associated with worse mental health (−2.43 units; 95%CI −4.22 to −0.64; p < 0.01). After accounting for COPD and other covariates, smoking was not associated with changes in physical or mental health.

Conclusions

The presence of COPD, rather than smoking, is associated with worse quality of life independent of HIV infection. Diagnosis and management of COPD in former or current smokers with or at risk for HIV may further improve quality of life.

Keywords

Quality of life Chronic obstructive pulmonary disease Human immunodeficiency virus Injection drug use Smoking Tobacco use 

Abbreviations

ALIVE

AIDS Linked to the Intravenous Experience

BMI

Body mass index

CD4

CD4+ T-helper cells

CI

confidence interval

COPD

Chronic obstructive pulmonary disease

FEV1

Forced expiratory volume in 1 s

FVC

Forced vital capacity

HAART

Highly active antiretroviral therapy

HIV

Human immunodeficiency virus

IDU

Injection drug user

IQR

Interquartile range

MOS-HIV

Medical outcomes studies-human immunodeficiency virus

QOL

Quality of life

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • M. Bradley Drummond
    • 1
  • Gregory D. Kirk
    • 1
    • 2
  • Meredith C. McCormack
    • 1
  • Mariah M. Marshall
    • 2
  • Erin P. Ricketts
    • 2
  • Shruti H. Mehta
    • 2
  • Robert A. Wise
    • 1
  • Christian A. Merlo
    • 1
  1. 1.Department of MedicineSchool of Medicine, Johns Hopkins UniversityBaltimoreUSA
  2. 2.Department of EpidemiologyBloomberg School of Public Health, Johns Hopkins UniversityBaltimoreUSA