Quality of Life Research

, 17:377

The effects of exercise training on quality of life in HAART-treated HIV-positive Rwandan subjects with body fat redistribution

  • Eugene Mutimura
  • Aimee Stewart
  • Nigel J. Crowther
  • Kevin E. Yarasheski
  • W. Todd Cade
Article

DOI: 10.1007/s11136-008-9319-4

Cite this article as:
Mutimura, E., Stewart, A., Crowther, N.J. et al. Qual Life Res (2008) 17: 377. doi:10.1007/s11136-008-9319-4

Abstract

Objective

Our objective was to examine the effects of exercise training (EXS) on quality of life (QoL) in highly active antiretroviral therapy (HAART)-treated HIV-positive (HIV+) subjects with body fat redistribution (BFR) in Rwanda.

Methods

The effects of a randomised controlled trial of EXS on QoL were measured using World Health Organisation Quality of Life (WHOQOL)-BREF in HIV+ subjects with BFR randomised to EXS (n = 50; BFR + EXS) or no exercise training (n = 50; BFR + noEXS).

Results

At 6 months, scores on the psychological [1.3 (0.3) vs. 0.5 (0.1); P < 0.0001], independence [0.6 (0.1) vs. 0.0 (0.0); P < 0.0001], social relationships [0.6 (0.2) vs. 0.0 (0.0); P < 0.0001] and HIV HAART-specific QoL domains [1.4 (0.2) vs. −0.1 (0.2); P < 0.0001] improved more in BFR + EXS than BFR + noEXS group, respectively. Self-esteem [1.3 (0.8) vs. 0.1 (0.6); P < 0.001], body image [1.5 (0.6) vs. 0.0 (0.5); P < 0.001] and emotional stress [1.6 (0.7) vs. 0.2 (0.5); P < 0.001] improved more in the BFR + EXS group than BFR + noEXS group, respectively. Psychological [1.5 (0.2) vs. 1.1 (0.3); P < 0.0001], social relationship [0.8 (0.2) vs. 0.4 (0.2); P < 0.0001], and HIV HAART-specific well-being [1.8 (0.2) vs. 1.0 (0.0); P < 0.0001] improved more in BFR + EXS female than male subjects.

Conclusions

Exercise training improved several components of QoL in HAART-treated HIV+ African subjects with BFR. Exercise training is an inexpensive and efficacious strategy for improving QoL in HIV+ African subjects, which may improve HAART adherence and treatment initiatives in resource-limited areas of sub-Saharan Africa.

Keywords

Africa HAART Lipodystrophy Rwanda 

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Eugene Mutimura
    • 1
  • Aimee Stewart
    • 2
  • Nigel J. Crowther
    • 3
  • Kevin E. Yarasheski
    • 4
  • W. Todd Cade
    • 5
  1. 1.Faculty of Allied Health SciencesKigali Health InstituteKigaliRwanda
  2. 2.School of Therapeutic SciencesUniversity of the WitwatersrandJohannesburgSouth Africa
  3. 3.Department of Chemical Pathology, National Health Laboratory ServiceUniversity of the WitwatersrandJohannesburgSouth Africa
  4. 4.Division of Endocrinology, Metabolism & Lipid Research, Department of Internal MedicineWashington University School of MedicineSt. LouisUSA
  5. 5.Program in Physical TherapyWashington University School of MedicineSt. LouisUSA

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