The feasibility and responsiveness of the health utilities index in patients with early-stage breast cancer: A prospective longitudinal study
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
The health utilities index (HUI3) is a health measurement instrument based on individuals’ preferences for different health states. Breast cancer (BC) is common, with a high proportion of long-term survivors, making evaluation of treatment effects important. Feasibility and responsiveness of HUI3 was compared to the short-form 36 (SF-36) in patients with BC.
HUI3 and SF-36 were administered eight times: at initial surgical consultation, 1 week before surgery; 1 week, 3, 6, 12, 18, and 24 months after surgery. Effect size, analysis of variance, and Pearson product moment correlations were calculated. BC data were compared to normative values.
Eighty-five patients were enrolled. Ninety-one percent of planned assessments were completed. HUI3 showed significant responsiveness (P < 0.01) after surgery and during recovery. HUI3 scores correlated with SF-36 scores. Comparison to normative data demonstrated the significant detrimental effect of BC diagnosis. Results showed long-term effects of treatment on physical health and positive effects on mental/emotional health in BC survivors.
HUI3 was found to be feasible and responsive in our cohort of BC patients. Changes in HUI3 values over time, and compared to normative data, paralleled SF-36 scores. HUI3 is a valuable tool in health-related quality of life and cost-utility studies in patients with BC.
- Ferlay, J., Bray, F., Pisani, P., & Parkin, D. M. (2001). Cancer incidence, mortality and prevalence worldwide, Version 1.0 IARC CancerBase No. 5. Lyon, IARC Press.
- Moyer, A. (1997). Psychosocial outcomes of breast conserving surgery versus mastectomy: A meta-analytic review. Health Psychology, 16, 284–298. CrossRef
- Casso, D., Buist, D. S. M., & Taplin, S. (2004). Quality of life of 5–10 year breast cancer survivors diagnosed between age 40 and 49. Health and Quality of Life Outcomes, 2, 25. CrossRef
- Guyatt, G. H., Feeny, D. H., & Patrick, D. L. (1993). Measuring health-related quality of life: Basic sciences review. Annals of Internal Medicine, 70, 225–230.
- Cella, D. F., & Tulsky, D. S. (1990). Measuring quality of life today: methodological aspects. Oncology, 5, 29–38.
- Guyatt, G. H., Naylor, C. D., Juniper, E., Heyland, D. K., Jaeschke, R., & Cook, D. J. (1997). Users’ guides to the medical literature XII. How to use articles about health-related quality of life. Journal of the American Medical Association, 277, 1232–1237. CrossRef
- Wright, J. G. (2000). Evaluating the outcome of treatment: Shouldn’t we be asking patients if they are better? Journal of Clinical Epidemiology, 53, 549–553. CrossRef
- Feeny, D., Furlong, W., Torrance, G. W., Goldsmith, C. H., Zhu, Z., DePauw, S., et al. (2002). Multiattribute and single-attribute utility functions for the health utilities index mark 3 system. Medical Care, 40, 113–228. CrossRef
- Horsman, J., Furlong, B., Feeny, D., & Torrance, G. (2003). The Health Utilities Index (HUI): Concepts, measurement properties, and applications. Health and Quality of Life Outcomes, 1, 54. CrossRef
- Jones, C. A., Feeny, D., & Eng, K. (2005). Test–retest reliability of health utilities index scores: Evidence from hip fracture. International Journal of Technology Assessment in Health Care, 21(3), 393–398.
- Blanchard, C., Feeny, D. H., Mahon, J. L., Bourne, R., Rorabeck, C., Stitt, L., et al. (2003). Is the Health Utilities Index responsive in total hip arthroplasty patients? Journal of Clinical Epidemiology, 56(11), 1046–1054. CrossRef
- Drummond, M. (2001). Introducing economic and quality of life measurements into clinical studies. Annals of Medicine, 33, 344–349.
- Grootendorst, P., Feeny, D., & Furlong, W. (2000). Health Utilities Index Mark 3: Evidence of construct validity for stroke and arthritis in a population health survey. Medical Care, 38(3), 290–299. CrossRef
- Brooks, R. (1996). EuroQol: The current state of play. Health Policy, 37, 53–72. CrossRef
- Tsuchiya, A., Brazier, J., & Roberts, J. (2006). Comparisons of valuation methods used to generate the EQ-5D and the SF-6D value sets. Journal of Health Economics, 25(2), 334–346. CrossRef
- Kaplan, R. M., Anderson, J. P., Wu, A. W., Mathews, C., Kozin, F., & Orenstein, D. (1989). The quality of well-being scale: Applications in AIDS, cystic fibrosis and arthritis. Medical Care, 27, S27–S43. CrossRef
- Gelber, R. D., Bonetti, M., Cole, B. F., Gelber, S., & Goldhirsch, A. (1998). Quality of life assessment in the adjuvant setting: it is relevant? International breast cancer study group. Recent Results in Cancer Research, 152, 373–389.
- Fisher, B., Anderson, S., Bryant, J., Margolese, R. G., Deutsch, M., Fisher, E. R., et al. (2002). Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. The New England Journal of Medicine, 347, 1233–1241. CrossRef
- Veronesi, U., Cascinelli, N., Mariani, L., Greco, M., Saccozzi, R., Luini, A., et al. (2002). Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early stage breast cancer. The New England Journal of Medicine, 347, 1227–1232. CrossRef
- Poggi, M. M., Danforth, D. N., Sciuto, L. C., Smith, S. L., Steinberg, S. M., Liewehr, D. J., et al. (2003). Eighteen-year results in the treatment of early breast carcinoma with mastectomy versus breast conservation therapy: The National Cancer Institute randomized trial. Cancer, 9, 697–702. CrossRef
- Schain, W. S., d’Angelo, T. M., Dunn, M. E., Lickter, A. S., & Pierce, L. J. (1994). Mastectomy versus conservative surgery and radiation therapy: Psychosocial consequences. Cancer 73, 1221–1228. CrossRef
- Margolis, G., Goodman, R. L., & Rubin, A. (1990). Psychological effects of breast-conserving cancer treatment and mastectomy. Psychosomatics, 31, 33–39.
- Al-Ghazal, S. K., Fallowfield, L., & Blamey, R. W. (2000). Comparison of psychological aspects and patient satisfaction following breast conserving surgery, simple mastectomy and breast reconstruction. European Journal of Cancer, 36, 1938–1943. CrossRef
- Shimozuma, K., Ganz, P. A., Petersen, L., & Hirji, K. (1999). Quality of life in the first year after breast cancer surgery: Rehabilitation needs and patterns of recovery. Breast Cancer Research and Treatment 56, 45–57. CrossRef
- Ganz, P. A., Kwan, L., Stanton, A. L., & Krupnick, J. L. (2004). Quality of life at the end of primary treatment of breast cancer: First results from the moving beyond cancer randomized trial. Journal of the National Cancer Institute, 96, 376–387. CrossRef
- Avis, N. E., Crawford, S., & Manuel, J. (2005). Quality of life among younger women with breast cancer. Journal of Clinical Oncology, 23, 3322–3330. CrossRef
- Wenzel, L. B., Fairclough, D. L., Brady, M. J., Cella, D., Garrett, K. M., Klushman, B. C., et al. (1999). Age-related differences in the quality of life of breast carcinoma patients after treatment. Cancer, 86, 1768–1774. CrossRef
- Ganz, P. A., Coscarelli, A., Fred, C., Kahn, B., Polinsky, M. L., & Petersen, L. (1996). Beast cancer survivors: Psychosocial concerns and quality of life. Breast Cancer Research and Treatment, 38, 183–199. CrossRef
- Ganz, P. A., Rowland, J. H., Desmond, K., Meyerowitz, B. E., & Wyatt, G. E. (1998). Life after breast cancer: Understanding women’s health-related quality of life and sexual functioning. Journal of Clinical Oncology, 16, 501–514.
- Ganz, P. A., Desmond, K. A., Leedham, B., Rowland, J. H., Meyerowitz, B. E., & Belin, T. R. (2002). Quality of life in long-term, disease-free survivors of breast cancer: A follow-up study. Journal of the National Cancer Institute, 94, 39–49.
- Wapnir, I. L., Cody, R. P., & Greco, R. S. (1999). Subtle differences in quality of life after breast cancer surgery. Annals of Surgical Oncology, 6, 359–366. CrossRef
- Arndt, V., Sturmer, T., Stegmaier, C., Ziegler, H., & Brenner, H. (2004). Age-specific detriments to quality of life among breast cancer patients one year after diagnosis. European Journal of Cancer, 40, 673–680. CrossRef
- Bardwell, W. A., Major, J. M., Rock, C. L., Newman, V. A., Thomson, C. A., Chilton, J. A., et al. (2004). Health-related quality of life in women previously treated for early-stage breast cancer: For the Women’s Healthy Eating and Living (WHEL) Study Group. Psycho-Oncology, 13, 595–604. CrossRef
- Arora, N. K., Gustafson, D. H., Hawkins, R. P., McTavish, F., Cella, D. F., Pingree, S., et al. (2001). Impact of surgery and chemotherapy on the quality of life of younger women with beast carcinoma. Cancer, 92, 1288–1298. CrossRef
- Maunsell, E., Brisson, J., & Deschenes, L. (1993). Arm problems and psychological distress after surgery for breast cancer. Canadian Journal of Surgery 36, 315–320.
- Ververs, J. M., Roumen, R. M., Vingerhoets, A. J., Vreugdenhil, G., Coebergh, J. W., Crommelin, M. A., et al. (2001). Risk, severity and predictors of physical and psychological morbidity after axillary lymph node dissection for breast cancer. European Journal of Cancer, 37, 991–999. CrossRef
- Polsky, D., Keating, N. L., Weeks, J. C., & Schulman, K. A. (2002). Patient Choice of Breast Cancer Treatment: Impact on health state preference. Medical Care, 40, 1068–1079. CrossRef
- Hopman, W. M., Towheed, T., Anastassiades, T., Tenenhouse, A., Poliquin, S., Berger, C., et al. (2000). Canadian normative data for the SF-36 health survey. Can Med Assoc J, 163, 265–271.
- Statistics Canada. General Social Survey (1991), Public use microdata file documentation and user’s guide. Ottawa, Ontario Ministry of Industry and Science and Technology; 1992.
- Statistics Canada. (1995). NPHS public use microdata documentation. Ottawa, Ontario.
- Ware, J. E. Jr., Snow, K. K., Kosinski, M., & Gandek, B. SF-36 health survey: Manual and interpretation guide. Boston, MA, The Health Institute, New England Medical Center, 1993 and 2005 editions.
- Lovrics, P. J., Chen, V., Coates, G., Cornacchi, S., Goldsmith, C. H., Law, C., et al. (2004). A prospective evaluation of positron emission tomography scanning, sentinel lymph node biopsy, and standard axillary dissection for axillary staging in patients with early stage breast cancer. Annals of Surgical Oncology, 11, 846–853. CrossRef
- Statistics Canada: Canadian Community Health Survey, Cycle 1.1 (2000–2001).
- Terwee, C. B., Dekker, F. W., Wiersinga, W. M., Prummel, M. F., & Bossuyt, P. M. M. (2003). On assessing responsiveness of health-related quality of life instruments: Guidelines for instrument evaluation. Quality of Life Research, 12, 349–362. CrossRef
- Harrell, F. E. Jr. (2001). Regression modeling strategies with applications to linear models, logistic regression, and survival analysis. New York, NY, Springer-Verlag, pp. 41–49.
- Davis, J. A. (1971). Elementary survey analysis. Englewood Cliffs, NJ: Prentice-Hall.
- Cohen, J. (1998). Statistical power analysis for the behavioral sciences (2nd Edn.). Hillsdale, NJ: Lawrence Earlbaum Associates.
- Golden-Kreutz, D. M., Thornton, L. M., Wells-Di Gregorio, S., Frierson, G. M., Jim, H. S., Carpenter, K. M., et al. (2005). Traumatic stress, perceived global stress, and life events: Prospectively predicting quality of life in breast cancer patients. Health Psychology, 24(3), 288–296. CrossRef
- Anderson, B. L., Anderson, B., & deProsse, C. (1989). Controlled prospective longitudinal study of women with cancer II: Psychological outcomes. Journal of Consulting and Clinical Psychology, 57, 692–697. CrossRef
- Rowland, J. H., & Massie, M. J. (1998). Breast Cancer. In J. C. Holland (Ed.). Psycho-oncology (pp. 380–401), New York, NY: Oxford University Press.
- Ganz, P. A., Guadagnoli, E., Landrum, M. B., Lash, T. L., Rakowski, W., & Silliman, R. A. (2003). Breast cancer in older women: Quality of life and psychosocial adjustment in the 15 months after diagnosis. Journal of Clinical Oncology, 21(21), 4027–4033. CrossRef
- Krahn, M., Bremner, K. E., Tomlinson, G., Ritvo, P., Irvine, J., & Naglie, G. (2007). Responsiveness of disease-specific and generic utility instruments in prostate cancer patients. Quality of the Life Research, 16, 509–522. CrossRef
- Ramsey, S. D., Andersen, M. R., Etzioni, R., Moinpour, C., Peacock, S., Potosky, A., et al. (2000). Quality of life in survivors of colorectal carcinoma. Cancer, 88(6), 1294–1303. CrossRef
- Caffo, O., Amichetti, M., Ferro, A., Lucenti, A., Valduga, F., & Galligioni, E. (2003). Pain and quality of life after surgery for breast cancer. Breast Cancer Research and Treatment, 80(1), 39–48. CrossRef
- The feasibility and responsiveness of the health utilities index in patients with early-stage breast cancer: A prospective longitudinal study
Quality of Life Research
Volume 17, Issue 2 , pp 333-345
- Cover Date
- Print ISSN
- Online ISSN
- Springer Netherlands
- Additional Links
- Breast cancer
- Health Utilities Index
- Quality of life
- Industry Sectors
- Author Affiliations
- 1. Department of Surgery, Hamilton Health Sciences and St. Joseph’s Healthcare, McMaster University, Hamilton, ON, Canada, L8N 4A6
- 2. Surgical Outcomes Research Centre, McMaster University, Hamilton, ON, Canada
- 3. Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada
- 4. Department of Medicine and Supportive Cancer Care Research Unit, Juravinski Cancer Centre, McMaster University, Hamilton, ON, Canada
- 5. St. Joseph’s Healthcare, Biostatistics Unit, Father Sean O’Sullivan Research Centre, Hamilton, ON, Canada