Quality of Life Research

, Volume 16, Issue 7, pp 1231–1237

Validation of the Migraine-Specific Quality of Life Questionnaire version 2.1 (MSQ v. 2.1) for patients undergoing prophylactic migraine treatment

Original Paper

DOI: 10.1007/s11136-007-9217-1

Cite this article as:
Cole, J.C., Lin, P. & Rupnow, M.F.T. Qual Life Res (2007) 16: 1231. doi:10.1007/s11136-007-9217-1

Abstract

Objective

Health-related quality of life (HRQoL) is an important outcome measure of migraine treatments. Although a number of migraine-specific HRQoL questionnaires exist, their measurement characteristics have only been examined for patients undergoing acute treatment of migraine. The goal of the current study was to evaluate measurement properties of the widely used Migraine-Specific Quality of Life Questionnaire version 2.1 (MSQ v. 2.1) within a group of patients undergoing prophylactic migraine treatment.

Methods

Various measurement properties of the MSQ were examined in a sample of 916 migraineurs undergoing prophylactic treatment who had scores at baseline and follow-up, as well as baseline SF-36. First, we used confirmatory factor analysis (CFA) and differential item functioning (DIF) to assure the accuracy and stability across groups of the MSQ scoring for all three subscales (Role Restrictive, Role Preventive, and Emotional Functioning). Next, item- and scale-level properties were examined, such as item-total correlations, internal consistency, and convergent and discriminant validity.

Results

Initial findings revealed that item 12 (measuring frustration on the Emotional Functioning subscale) performed poorly. Subsequent to its removal, the 13-item MSQ displayed excellent measurement properties, including stable latent structure at baseline and endpoint, no gender or age biases on items, appropriate item-level and scale-level reliabilities, and markedly higher convergent validity compared to discriminant validity.

Conclusion

The 13-item MSQ appears to be an appropriate measure of migraine-specific HRQoL for patients undergoing migraine prophylaxis. Moreover, given the stability of the latent structure over time, the interpretation of scores is likely to remain quite consistent throughout a clinical trial.

Keywords

MSQPsychometricsQuality of lifeMigraineMigraine prophylaxis

Abbreviations

CFA

Confirmatory factor analysis

CFI

Comparative fit index

DIF

Differential item functioning

EF

MSQ emotional function domain

GFI

Goodness of fit index

HDI

Headache Disability Inventory

HIT-6

Headache Impact Test 6-item

IRT

Item response theory

MSQ

Migraine-Specific Quality of Life Questionnaire

NNFI

Nonnormed fit index

RMSEA

Root mean square error of approximation

RP

MSQ role preventive domain

RR

MSQ role restrictive domain

SF-36

Medical Outcomes Study Short Form 36

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Jason C. Cole
    • 1
  • Peggy Lin
    • 1
  • Marcia F. T. Rupnow
    • 2
  1. 1.QualityMetricLincolnUSA
  2. 2.Ortho-McNeil-Janssen Scientific AffairsTitusvilleUSA