Quality of Life Research

, Volume 16, Issue 6, pp 947–960

Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report

  • Kathleen Meeske
  • Ashley Wilder Smith
  • Catherine M. Alfano
  • Bonnie A. McGregor
  • Anne McTiernan
  • Kathy B. Baumgartner
  • Kathleen E. Malone
  • Bryce B. Reeve
  • Rachel Ballard-Barbash
  • Leslie Bernstein
Article

DOI: 10.1007/s11136-007-9215-3

Cite this article as:
Meeske, K., Smith, A.W., Alfano, C.M. et al. Qual Life Res (2007) 16: 947. doi:10.1007/s11136-007-9215-3
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Abstract

Purpose The purpose of this study was to estimate prevalence of fatigue, identify correlates of fatigue and evaluate the relationship between fatigue and health-related quality of life (HRQOL) in a large cohort of disease-free breast cancer survivors.

Methods Participants are enrolled in the HEAL Study, a multi-center prospective study of women diagnosed with in-situ to Stage IIIA breast cancer. HEAL participants (n = 1183) completed a baseline and a 24-month follow-up interview. Women in this report (n = 800) also completed a quality of life questionnaire that included the Piper Fatigue Scale and the RAND SF-36 two to five years after diagnosis. Multivariate regression methods were used to identify significant factors associated with fatigue. SF-36 scores for fatigued survivors were compared to non-fatigued survivor scores and population norms.

Results Forty-one percent of the breast cancer survivors were fatigued. Significant correlates of fatigue included pain, cognitive problems, physical inactivity, weight gain/personal appearance and antidepressant use. Fatigue was associated with poorer HRQOL, most notably in areas of role and social functioning.

Conclusion This study provides further support for the conclusion that a significant proportion of breast cancer survivors experience fatigue that compromises HRQOL two to five years post-diagnosis.

Keywords

Breast cancer survivorsFatigueQuality of lifePiper Fatigue Scale

Abbreviations

HRQOL

Health-Related Quality Of Life

QOL

Quality Of Life

SEER

Surveillance, Epidemiology and End Results

HEAL

Health, Eating, Activity and Lifestyle

OR

Odds Ratio

R-PFS

Revised-Piper Fatigue Scale

BCPT

Breast Cancer Prevention Trial

HSC

Hormone-related Symptom Checklist

SF-36

Short Form-36

sd

Standard deviation

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Kathleen Meeske
    • 1
  • Ashley Wilder Smith
    • 2
  • Catherine M. Alfano
    • 3
  • Bonnie A. McGregor
    • 4
  • Anne McTiernan
    • 4
  • Kathy B. Baumgartner
    • 5
  • Kathleen E. Malone
    • 4
  • Bryce B. Reeve
    • 2
  • Rachel Ballard-Barbash
    • 2
  • Leslie Bernstein
    • 1
  1. 1.Department of Preventive MedicineKeck School of Medicine of the University of Southern California, USC/Norris Comprehensive Cancer CenterLos AngelesUSA
  2. 2.Outcomes Research Branch, Applied Research Program, Division of Cancer Control and Population SciencesNational Cancer Institute, EPN 4005BethesdaUSA
  3. 3.College of Public Health and Comprehensive Cancer CenterThe Ohio State UniversityColumbusUSA
  4. 4.Fred Hutchinson Cancer Research CenterSeattleUSA
  5. 5.Epidemiology and Clinical Investigation Sciences, School of Public Health & Information SciencesUniversity of LouisvilleLouisvilleUSA