Quality of Life Research

, 16:577

Health-related quality of life in HIV-1-infected patients on HAART: a five-years longitudinal analysis accounting for dropout in the APROCO-COPILOTE cohort (ANRS CO-8)

  • Camelia Protopopescu
  • Fabienne Marcellin
  • Bruno Spire
  • Marie Préau
  • Renaud Verdon
  • Dominique Peyramond
  • François Raffi
  • Geneviève Chêne
  • Catherine Leport
  • Maria-Patrizia Carrieri
Original Paper

DOI: 10.1007/s11136-006-9151-7

Cite this article as:
Protopopescu, C., Marcellin, F., Spire, B. et al. Qual Life Res (2007) 16: 577. doi:10.1007/s11136-006-9151-7

Abstract

Background

The long-term efficacy of Highly Active Antiretroviral Therapies (HAART) has enlightened the crucial role of health-related quality of life (HRQL) among HIV-infected patients. However, any analysis of such extensive longitudinal data necessitates a suitable handling of dropout which may correlate with patients–health status.

Methods

We analysed the HRQL evolution over 5 years for 1,000 patients initiating a protease inhibitor (PI)-containing therapy, using MOS SF-36 physical (PCS) and mental (MCS) scores. In parallel with a classical separate random effects model, we used a joint parameter-dependent selection model to account for non-ignorable dropout.

Results

HRQL evolved according to a two-phase pattern, characterized by an initial improvement during the year following HAART initiation and a relative stabilization thereafter. Immunodepression and self-reported side effects were found to be negative predictors of both PCS and MCS scores. Hepatitis C virus coinfection and AIDS clinical stage were found to affect physical HRQL. Results were not significantly altered when accounting for dropout.

Conclusion

Such results, obtained on a large sample of HIV-infected patients with extensive follow-up, underline the need for a regular monitoring of patients–immunological status and for a better management of their experience with hepatitis C and HAART.

Keywords

HIVHAARTQuality of lifeHepatitis CDropout

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Camelia Protopopescu
    • 1
    • 2
  • Fabienne Marcellin
    • 1
    • 2
  • Bruno Spire
    • 1
    • 2
  • Marie Préau
    • 1
    • 2
  • Renaud Verdon
    • 3
  • Dominique Peyramond
    • 4
  • François Raffi
    • 5
  • Geneviève Chêne
    • 6
  • Catherine Leport
    • 7
  • Maria-Patrizia Carrieri
    • 1
    • 2
  1. 1.Health and Medical Research National Institute (INSERM), Research Unit 379, Social Sciences Applied to Medical InnovationMarseillesFrance
  2. 2.Southeastern Health Regional Observatory (ORS-PACA)MarseillesFrance
  3. 3.CHU de la Côte de NacreCaenFrance
  4. 4.Croix-Rousse HospitalLyonFrance
  5. 5.Hôtel-DieuNantesFrance
  6. 6.INSERM Research Unit 330BordeauxFrance
  7. 7.Faculté Xavier BichatParisFrance