Quality of Life Research

, 16:545

Factors associated with health-related quality of life among hemodialysis patients in the DOPPS

  • Antonio Alberto Lopes
  • Jennifer L. Bragg-Gresham
  • David A. Goodkin
  • Shunichi Fukuhara
  • Donna L. Mapes
  • Eric W. Young
  • Brenda W. Gillespie
  • Tadao Akizawa
  • Roger N. Greenwood
  • Vittorio E. Andreucci
  • Takashi Akiba
  • Philip J. Held
  • Friedrich K. Port
ORIGINAL PAPER

DOI: 10.1007/s11136-006-9143-7

Cite this article as:
Lopes, A.A., Bragg-Gresham, J.L., Goodkin, D.A. et al. Qual Life Res (2007) 16: 545. doi:10.1007/s11136-006-9143-7

Abstract

Objective

To identify modifiable factors associated with health-related quality of life (HRQOL) among chronic hemodialysis patients.

Methods

Analysis of baseline data of 9,526 hemodialysis patients from seven countries enrolled in phase I of the Dialysis Outcomes and Practice Patterns Study (DOPPS). Using the Kidney Disease Quality of Life Short Form (KDQOL-SFTM), we determined scores for 8 generic scale summaries derived from these scales, i.e., the physical component summary [PCS] and mental component summary [MCS], and 11 kidney disease-targeted scales. Regression models were used to adjust for differences in comorbidities and sociodemographic and treatment factors. The Benjamin-Hochberg procedure was used to correct P-values for multiple comparisons.

Results

Unemployment and psychiatric disease were independently and significantly associated with lower scores for all generic and several kidney disease-targeted HRQOL measures. Several other comorbidities, lower educational level, lower income, and hypoalbuminemia were also independently and significantly associated with lower scores of PCS and/or MCS and several generic and kidney disease-targeted scales. Hemodialysis by catheter was associated with significantly lower PCS scores, partially explained by the correlation with covariates.

Conclusion

Associations of poorer HRQOL with preventable or controllable factors support a greater focus on psychosocial and medical interventions to improve the well-being of hemodialysis patients.

Keywords

DOPPSEnd-stage renal disease (ESRD)HemodialysisKDQOL-SFOutcomes

Abbreviation List

HRQOL

Health-related quality of life

DOPPS

Dialysis Outcomes and Practice Patterns Study

KDQOL-SF

Kidney Disease Quality of Life Short Form

PCS

Physical Component Summaries

MCS

Mental Component Summaries

ESRD

End-stage renal disease

SF-36

Short-Form Health Survey

SBP

Systolic blood pressure

NPCR

Normalized protein catabolic rate

BMI

Body Mass Index

ADIFS

Adjusted difference in score

eKt/V

Equilibrated Kt/V (dialysis dose)

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Antonio Alberto Lopes
    • 1
    • 2
  • Jennifer L. Bragg-Gresham
    • 3
  • David A. Goodkin
    • 3
    • 4
  • Shunichi Fukuhara
    • 5
  • Donna L. Mapes
    • 3
  • Eric W. Young
    • 6
  • Brenda W. Gillespie
    • 2
    • 3
  • Tadao Akizawa
    • 7
  • Roger N. Greenwood
    • 8
  • Vittorio E. Andreucci
    • 9
  • Takashi Akiba
    • 10
  • Philip J. Held
    • 3
  • Friedrich K. Port
    • 3
  1. 1.Department of MedicineFederal University of BahiaSalvadorBrazil
  2. 2.University of MichiganAnn ArborUSA
  3. 3.Arbor Research Collaborative for Health/formerlyUniversity Renal Research and Education Association (URREA)Ann ArborUSA
  4. 4.ICOS CorporationBothellUSA
  5. 5.Graduate School of Medicine and Public HealthKyoto UniversityKyotoJapan
  6. 6.Division of NephrologyUniversity of Michigan and VAMCAnn ArborUSA
  7. 7.Wakayama Medical UniversityWakayamaJapan
  8. 8.Lister HospitalStevenageUK
  9. 9.Università Federico IINaplesItaly
  10. 10.Tokyo Women’s Medical UniversityTokyoJapan