Factors associated with health-related quality of life among hemodialysis patients in the DOPPS
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To identify modifiable factors associated with health-related quality of life (HRQOL) among chronic hemodialysis patients.
Analysis of baseline data of 9,526 hemodialysis patients from seven countries enrolled in phase I of the Dialysis Outcomes and Practice Patterns Study (DOPPS). Using the Kidney Disease Quality of Life Short Form (KDQOL-SFTM), we determined scores for 8 generic scale summaries derived from these scales, i.e., the physical component summary [PCS] and mental component summary [MCS], and 11 kidney disease-targeted scales. Regression models were used to adjust for differences in comorbidities and sociodemographic and treatment factors. The Benjamin-Hochberg procedure was used to correct P-values for multiple comparisons.
Unemployment and psychiatric disease were independently and significantly associated with lower scores for all generic and several kidney disease-targeted HRQOL measures. Several other comorbidities, lower educational level, lower income, and hypoalbuminemia were also independently and significantly associated with lower scores of PCS and/or MCS and several generic and kidney disease-targeted scales. Hemodialysis by catheter was associated with significantly lower PCS scores, partially explained by the correlation with covariates.
Associations of poorer HRQOL with preventable or controllable factors support a greater focus on psychosocial and medical interventions to improve the well-being of hemodialysis patients.
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- Factors associated with health-related quality of life among hemodialysis patients in the DOPPS
Quality of Life Research
Volume 16, Issue 4 , pp 545-557
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- Springer Netherlands
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- End-stage renal disease (ESRD)
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- Author Affiliations
- 1. Department of Medicine, Federal University of Bahia, Salvador, Brazil
- 2. University of Michigan, Ann Arbor, MI, USA
- 3. Arbor Research Collaborative for Health/formerly, University Renal Research and Education Association (URREA), 315 W. Huron, Suite 260, Ann Arbor, MI, 48103, USA
- 4. ICOS Corporation, Bothell, WA, USA
- 5. Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan
- 6. Division of Nephrology, University of Michigan and VAMC, Ann Arbor, MI, USA
- 7. Wakayama Medical University, Wakayama, Japan
- 8. Lister Hospital, Stevenage, UK
- 9. Università Federico II, Naples, Italy
- 10. Tokyo Women’s Medical University, Tokyo, Japan