Quality of Life Research

, 16:533

Determinants of health related quality of life and health state utility in patients with age related macular degeneration: the association of contrast sensitivity and visual acuity

  • N. Bansback
  • C. Czoski-Murray
  • J. Carlton
  • G. Lewis
  • L. Hughes
  • M. Espallargues
  • C. Brand
  • J. Brazier
Article

DOI: 10.1007/s11136-006-9126-8

Cite this article as:
Bansback, N., Czoski-Murray, C., Carlton, J. et al. Qual Life Res (2007) 16: 533. doi:10.1007/s11136-006-9126-8

Abstract

Background

There has been increasing interest in the use of measures of health related quality of life (HRQoL) and health state utility values in Age Related Macular Degeneration (ARMD). Visual acuity has been found to be an important determinant of such measures in previous studies. More recently, another measure of visual impairment, contrast sensitivity has received considerable attention. We designed a study to examine whether the contribution of contrast sensitivity in explaining HRQoL and health utilities over and above that of visual acuity.

Methods

209 patients with unilateral or bilateral ARMD were recruited into a cross-sectional study of patients from a large teaching hospital. Patients underwent visual tests (near and distant visual acuity, contrast sensitivity) and completed a vision function questionnaire, the VF-14, HUI3, and time trade-off.

Results

Using multivariate regression analysis, the study revealed that contrast sensitivity remained a statistically significant predictor of all outcome measures even when visual acuity was included. This result was supported by the correlation coefficients between measures.

Conclusions

The measurement of contrast sensitivity appears to be better related to a person’s HRQoL and health utility. Future studies should consider incorporating contrast sensitivity in addition to visual acuity. Studies, in particular economic evaluations, may underestimate the effect of treatment unless contrast sensitivity is considered.

Keywords

Age related macular degeneration Contrast sensitivity Health status Visual acuity 

Abbreviations:

ARMD

age related macular degeneration

CS

contrast sensitivity

VA

visual acuity

VF

visual function

HUI

health utilities index

HRQol

health related quality of life

TTO

time trade off

SG

standard gamble

LogMAR

logarithm of the minimum angle of resolution

Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • N. Bansback
    • 1
  • C. Czoski-Murray
    • 1
  • J. Carlton
    • 3
  • G. Lewis
    • 3
  • L. Hughes
    • 3
  • M. Espallargues
    • 1
    • 2
  • C. Brand
    • 4
  • J. Brazier
    • 1
  1. 1.Health Economics and Decision ScienceScHARR (School of Health and Related Research), The University of SheffieldSheffieldUK
  2. 2.Catalan Agency for Health Technology Assessment and ResearchCatalan Health ServiceCatalanSpain
  3. 3.Department of OrthopticsSheffield Teaching Hospitals NHS TrustSheffieldUK
  4. 4.Department of OphthalomologySheffield Teaching Hospitals NHS TrustSheffieldUK