CDLQI, Scorad and Ness: Are they Correlated?
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Quality of life (QOL) and clinical severity scores are important parameters in the evaluation of distress experienced by children with atopic dermatitis (AD). The SCORing Atopic Dermatitis (SCOARD) is a widely used clinical score for assessing AD symptomatology over the preceding 3 days and the Nottingham Eczema Severity Score (NESS) is another score useful for AD symptoms over the preceding 12 months.
We evaluated if these parameters are correlated with QOL in children with AD.
We assessed quality of life, clinical scores, total IgE and eosinophil count in peripheral blood in AD patients at our paediatric dermatology clinic over a 14-month period.
Eighty AD patients (42 males and 38 females; mean [SD] age 11.7 [3.7] years) were recruited. The median (interquartile range, IQR) IgE, eosinophil counts and eosinophil percentage were 2988 (1069–7847) kIU/L; 0.6 (0.4–0.9) × 10−9/L; and 9 (6–12)%, respectively. Quality of life as measured with CDLQI (The Children’s Dermatology Life Quality Index) generally did not correlate well with both the acute and chronic AD severity scores (objective SCORAD and total CDQLI, ρ = 0.17, p > 0.05; total NESS and total CDQLI, ρ = 0.29, p < 0.05). Factor analysis further confirmed that the objective indicators (serum total IgE, eosinophil count and objective SCORAD), self-reported scores (NESS and subjective SCORAD) and CDLQI were separate dimensions in the assessment of AD in children.
Quality of life, disease severity scores and laboratory atopic markers represent different domains in AD assessment. They do not necessarily correlate well with each other and all three aspects must be individually evaluated to assess the well-being of these patients.
- Charman C, Williams H (2000) Outcome measures of disease severity in atopic eczema. Arch Dermatol 136:763–769 CrossRef
- Charman C, Chambers C, Williams H (2003) Measuring atopic dermatitis severity in randomized controlled clinical trials: What exactly are we measuring? J Invest Dermatol 120:932–941 CrossRef
- Severity scoring of atopic dermatitis: The SCORAD index (1993) Consensus report of the european task force on atopic dermatitis. Dermatology 186:23–31 CrossRef
- Rees JL, Laidlaw A. (1999) Pruritus: More scratch than itch. Clin Exp Dermatol 24:490–493 CrossRef
- Kunz B, Oranje AP, Labreze L et al. (1997) Clinical validation and guidelines for the SCORAD index: Consensus report of the European Task Force on Atopic Dermatitis. Dermatology 195:10–19
- Hon KL, Leung TF, Fok TF, et al. Subjective symptoms do not correlate well with disease extent or intensity in children with atopic dermatitis: PA-22. Br J Dermatol Suppl 2005; 153(Suppl 1): 89.
- Chuh AA (2003) Validation of a Cantonese version of the Children’s Dermatology Life Quality Index. Pediatr Dermatol 20:479–481 CrossRef
- Ben Gashir MA, Seed PT, Hay RJ (2002) Are quality of family life and disease severity related in childhood atopic dermatitis? J Eur Acad Dermatol Venereol 16:455–462 CrossRef
- Ben Gashir MA (2003) Relationship between quality of life and disease severity in atopic dermatitis/eczema syndrome during childhood. Curr Opin Allergy Clin Immunol 3:369–373 CrossRef
- Ben Gashir MA, Seed PT, Hay RJ (2004) Quality of life and disease severity are correlated in children with atopic dermatitis. Br J Dermatol 150:284–290 CrossRef
- Emerson RM, Charman CR, Williams HC (2000). The Nottingham Eczema Severity Score: Preliminary refinement of the Rajka and Langeland grading. Br J Dermatol 142:288–297 CrossRef
- Lewis-Jones MS, Finlay AY (1995). The Children’s Dermatology Life Quality Index (CDLQI): Initial validation and practical use. Br J Dermatol 132:942–949 CrossRef
- Hanifin JM, Rajka G (1980) Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 2:44–47
- Hon KL, Ma KC, Wong E et al. (2003) Validation of a self-administered questionnaire in Chinese in the assessment of eczema severity. Pediatr Dermatol 20:465–469 CrossRef
- Hon KL, Leung TF, Ma KC et al. (2004) Urinary leukotriene E4 correlates with severity of atopic dermatitis in children. Clin Exp Dermatol 29:277–281 CrossRef
- Multivariate methods. In: Armitage P, Berry G, Matthews JN (eds), Statistical Methods in Medical Research. Oxford, UK: Blackwell Science 2002: 455–484.
- Stevens J. (1996) Exploratory and confirmatory factor analysis. In: Stevens J, (eds) Applied Multivariate Statistics for the Social Sciences. Mahwah, NJ, Lawrence Erlbaum Associates, pp. 362–428
- Cattell RB (1966). The Scree test for the number of factors. Multivariate Behav Res 1:245–276 CrossRef
- Leung TF, Ma KC, Hon KL et al. (2003) Serum concentration of macrophage-derived chemokine may be a useful inflammatory marker for assessing severity of atopic dermatitis in infants and young children. Pediatr Allergy Immunol 14:296–301 CrossRef
- Hon KL, Leung TF, Ma KC et al. (2004) Serum levels of cutaneous T-cell attracting chemokine (CTACK) as a laboratory marker of the severity of atopic dermatitis in children. Clin Exp Dermatol 29:293–296 CrossRef
- Hon KL, Lam MC, Leung TF, et al. Nocturnal wrist movements are correlated with objective clinical scores and plasma chemokine levels in children with atopic dermatitis. Br J Dermatol 2006; 154: 629–635
- Hon KL, Leung TF, Ma KC et al. (2005) Resting energy expenditure, oxygen consumption and carbon dioxide production during sleep in children with atopic dermatitis. J Dermatolog Treat 16:22–25 CrossRef
- Leung TF, Wong GW, Ko FW, et al. (2005) Clinical and atopic parameters and airway inflammatory markers in childhood asthma: a factor analysis. Thorax 60:822–826 CrossRef
- Juniper EF, Wisniewski ME, Cox FM et al. (2004) Relationship between quality of life and clinical status in asthma: A factor analysis. Eur Respir J 23:287–291 CrossRef
- Tantisira KG, Litonjua AA, Weiss ST et al. (2003) Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP). Thorax 58:1036–1041 CrossRef
- Hon KL, Leung TF, Wong Y, Ma KC, Fok TF (2004). Skin diseases in Chinese children at a pediatric dermatology center. Pediatr Dermatol 21:109–112 CrossRef
- CDLQI, Scorad and Ness: Are they Correlated?
Quality of Life Research
Volume 15, Issue 10 , pp 1551-1558
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