Quality of Life Research

, Volume 15, Issue 3, pp 377–390

ISSQoL: A New Questionnaire for Evaluating the Quality of Life of People Living with HIV in the HAART Era*

  • R. Bucciardini
  • R. Murri
  • M. Guarinieri
  • F. Starace
  • M. Martini
  • A. Vatrella
  • L. Cafaro
  • M. Fantoni
  • R. Grisetti
  • A. d’Arminio Monforte
  • V. Fragola
  • R. Arcieri
  • C. Del Borgo
  • A. Tramarin
  • M. Massella
  • D. Lorenzetti
  • S. Vella
Article

DOI: 10.1007/s11136-005-3212-1

Cite this article as:
Bucciardini, R., Murri, R., Guarinieri, M. et al. Qual Life Res (2006) 15: 377. doi:10.1007/s11136-005-3212-1

Abstract

Objective: To design a Health-related Quality of Life (HRQoL) instrument for HIV-infected people in the era of highly active antiretroviral therapy (HAART). Methods: The self-administered questionnaire was developed by an Italian network including researchers, physicians, people living with HIV, national institutions and community-based organizations (CBO) through several steps: (1) review of existing HRQoL literature and questionnaires for HIV-infected people; (2) selection of relevant domains measuring HRQoL in HIV-infected people, and identification of new domains related to new aspects of HRQoL concerning HAART-treated individuals; (3) conduction of two pre-test analyses in independent groups of Italian HIV-positive people (n≌100) distributed throughout the country. The objectives of the first pre-test were to verify the usefulness of the questionnaire, to construct a form easily understandable by everyone, to define the domains and their significance; the second pre-test aimed at evaluating and reshaping the questionnaire based on a statistical analysis of the outcomes of first pre-test; (4) validation analysis. A large cohort of people with HIV infection was recruited for the last step.Results: The internal consistence reliability (Cronbach’s α) was ≥0.70 for all domains. Most domains had Cronbach’s coefficient >0.80. All domains demonstrated convergent and discriminant validity. The final version of ISSQoL includes two sections: HRQoL Core Evaluation Form (9 domains) and Additional Important Areas for HRQoL (6 domains). The ISSQoL was administered together with two additional forms: a Daily Impact of Symptoms Form and a Demographic Information Form. The Additional Important Areas for HRQoL include social support, interaction with medical staff, treatment impact, body changes, life planning, and motherhood/fatherhood.Conclusion: The data reported in the present paper provide preliminary evidence of the reliability and validity of the ISSQoL questionnaire for the measurement of HRQoL in HIV-infected people. The direct involvement of HIV-positive people in all the phases of the project was a key aspect of our work.

Keywords

HAARTHIVMOS-HIV Health SurveyQuality of lifeQuestionnaire

Copyright information

© Springer 2006

Authors and Affiliations

  • R. Bucciardini
    • 1
  • R. Murri
    • 2
  • M. Guarinieri
    • 3
  • F. Starace
    • 4
  • M. Martini
    • 5
  • A. Vatrella
    • 6
  • L. Cafaro
    • 4
  • M. Fantoni
    • 2
  • R. Grisetti
    • 7
  • A. d’Arminio Monforte
    • 7
  • V. Fragola
    • 1
  • R. Arcieri
    • 1
  • C. Del Borgo
    • 8
  • A. Tramarin
    • 9
  • M. Massella
    • 1
  • D. Lorenzetti
    • 10
  • S. Vella
    • 1
  1. 1.Department of Drug Research and EvaluationIstituto Superiore di SanitàRomeItaly
  2. 2.Università Cattolica del Sacro CuoreRomeItaly
  3. 3.I-CABBologneItaly
  4. 4.Ospedale D. CotugnoNaplesItaly
  5. 5.International Organization for MigrationRomeItaly
  6. 6.LILARomeItaly
  7. 7.Ospedale L. SaccoMilanItaly
  8. 8.IRCCS L. SpallanzaniRomeItaly
  9. 9.Ospedale S. BortoloVicenzaItaly
  10. 10.U.O. AIDS ASLRomeItaly