Quality of Life Research

, Volume 14, Issue 6, pp 1467–1479

Population-based study of the relationship of treatment and sociodemographics on quality of life for early stage breast cancer

Authors

    • Department of Health Behavior and Health Education, School of Public HealthUniversity of Michigan
  • Mahasin Mujahid
    • Department of Epidemiology, School of Public HealthUniversity of Michigan
  • Paula M. Lantz
    • Department of Health Management and PolicyUniversity of Michigan
  • Angela Fagerlin
    • Department of Internal MedicineUniversity of Michigan Health System
    • Veterans AffairsAnn Arbor Healthcare System
  • Barbara Salem
    • Department of Internal MedicineUniversity of Michigan Health System
  • Monica Morrow
    • Department of Surgical OncologyFox Chase Cancer Center
  • Dennis Deapen
    • Department of Preventive Medicine, KECK School of MedicineUniversity of Southern California
  • Steven J. Katz
    • Department of Health Management and PolicyUniversity of Michigan
    • Department of Internal MedicineUniversity of Michigan Health System
    • Veterans AffairsAnn Arbor Healthcare System
Article

DOI: 10.1007/s11136-005-0288-6

Cite this article as:
Janz, N.K., Mujahid, M., Lantz, P.M. et al. Qual Life Res (2005) 14: 1467. doi:10.1007/s11136-005-0288-6

Abstract

Objective: To examine the relationship between cancer stage, surgical treatment and chemotherapy on quality of life (QOL) after breast cancer and determine if sociodemographic characteristics modify the observed relationships. Methods: A population-based sample of women with Stages 0–II breast cancer in the United States (N=1357) completed surveys including the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), and the Breast Cancer-Specific Quality of Life Questionnaire (QLQ BR-23). Regression models calculated mean QOL scores across primary surgical treatment and chemotherapy. Clinically significant differences in QOL were defined as 10 point difference (out of 100) between groups. Results: Meaningful differences in QOL by surgical treatment were limited to body image with women receiving mastectomy with reconstruction reporting lower scores than women receiving breast conserving surgery (p < 0.001). Chemotherapy lowered QOL scores overall across four QOL dimensions (p values < 0.001), with a disproportionately greater impact on those with lower levels of education. Younger women reported lower QOL scores for seven of nine QOL dimensions (p values < 0.001). Conclusions: Women should be reassured that few QOL differences exist based on surgical treatment, however, clinicians should recognize that the impact of treatment on QOL does vary by a woman’s age and educational level.

Keywords

Breast cancerQuality of lifePsychosocial

Copyright information

© Springer 2005