Quality of Life Research

, Volume 14, Issue 5, pp 1401–1406

Cross-cultural adaptation and validation of the Korean version of the EQ-5D in patients with rheumatic diseases

  • Myoung-Hee Kim
  • Young-Shin Cho
  • Wan-Sik Uhm
  • Sehyun Kim
  • Sang-Cheol Bae

DOI: 10.1007/s11136-004-5681-z

Cite this article as:
Kim, MH., Cho, YS., Uhm, WS. et al. Qual Life Res (2005) 14: 1401. doi:10.1007/s11136-004-5681-z


Objectives: This study aimed to determine the cross-cultural adaptation and validation of the Korean version of the EQ-5D in rheumatic conditions. Methods: Translation, back-translation and cognitive debriefing were performed according to the EuroQol group’s guidelines. For validity, 508 patients were recruited and administered the EQ-5D, Short-Form 36 and condition-specific measures. Construct validity and sensitivity were evaluated by testing a-priori hypotheses. For reliability, another 57 patients repeated the EQ-5D at 1-week interval, and intra-class correlations (ICC) and kappa statistics were estimated. For responsiveness, another 60 patients repeated it at 12-week interval within the context of clinical trial, and standardized response mean(SRM) were calculated. Results: The cross-cultural adaptation produced no major modifications in the scale. The associations of the EQ-5D with the generic- and condition-specific measures were observed as expected in hypotheses the higher: EQ-5Dindex and EQ-5DVAS scores, the better health status by generic- or condition-specific measures, and the better functional class. The ICCs were 0.751 and 0.767, respectively, and kappa ranged from 0.455 to 0.772. The SRM were 0.649 and 0.410, respectively. Conclusion: The Korean EQ-5D exhibits good validity and sensitivity in various rheumatic conditions. Although its reliability and responsiveness were not excellent, it seems acceptable if condition-specific measures are applied together.


Quality of lifeReliability and validityRheumatic disease



ankylosing spondylitis


fibromyalgia syndrome


Health Survey Short-Form 36




rheumatoid arthritis


standardized response mean


systemic lupus erythematosus

Copyright information

© Springer 2005

Authors and Affiliations

  • Myoung-Hee Kim
    • 1
  • Young-Shin Cho
    • 2
  • Wan-Sik Uhm
    • 3
  • Sehyun Kim
    • 4
  • Sang-Cheol Bae
    • 3
  1. 1.Department of Preventive MedicineEulji University School of MedicineDaejeonRepublic of Korea
  2. 2.Department of Internal Medicine, Division of RheumatologyChosun UniversityGwangjooRepublic of Korea
  3. 3.Department of Internal Medicine, Division of Rheumatology, The Hospital for Rheumatic DiseasesHanyang UniversitySeoulRepublic of Korea
  4. 4.Department of Preventive MedicinePochon CHA UniversityKyonggiRepublic of Korea