Psychometric validation of the child health questionnaire (CHQ) in a sample of children and adolescents with attention-deficit/hyperactivity disorder
Cite this article as: Rentz, A.M., Matza, L.S., Secnik, K. et al. Qual Life Res (2005) 14: 719. doi:10.1007/s11136-004-0832-9 Abstract
Measuring health-related quality of life (HRQL) in children with attention-deficit/hyperactivity disorder (ADHD) in clinical trials can complement efficacy measures, offering a complete picture of the impact of disease and treatment on overall well-being. The purpose of the current study was to psychometrically validate a multidimensional, generic HRQL instrument completed by parents of children with ADHD. A total of 921 children and adolescents with ADHD participated in a clinical study of atomoxetine. Subjects’ parents completed the 50-item Child Health Questionnaire-Parent Version (CHQ-PF50) at baseline and week 10. ADHD symptoms and behavioral problems were assessed using parent and clinician rating scales. Internal consistency reliability at baseline was 0.88 for the CHQ-PF50 Psychosocial Summary Score, ranging from 0.53 to 0.91 for subscale scores. Construct validity was supported by statistically significant correlations between CHQ-PF50 psychosocial scores and parent and clinician symptom ratings. Several methods were used to determine clinically meaningful differences in patient outcomes: inter- and intra-patient mean CHQ-PF50 change scores were tested and standard error of measurement (SEM) and effect sizes were calculated. Study results indicate the CHQ-PF50 is reliable, valid, and responsive to change in ADHD symptoms, suggesting it may provide a means of assessing HRQL outcomes associated with treatments for ADHD.
Keywords Attention-deficit/hyperactivity disorder (ADHD) Child health questionnaire (CHQ) Health-related quality of life (HRQL) Psychometrics Responsiveness Abbreviations ADHD
attention-deficit/hyperactivity disorder rating scale-IV
analysis of covariance
analysis of variance
clinical global impressions-ADHD-improvement
clinical global impressions-ADHD-Severity
Child Health Questionnaire
28-item Child Health Questionnaire-Parent Version
50-item Child Health Questionnaire-Parent Version
Conners’ parent rating scale-revised: short form
diagnostic and statistical manual of mental disorders,fourth edition
health-related quality of life
Kiddie schedule for affective disorders and schizophrenia-present and lifetime version
standard error of measurement
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