Quality of Life Research

, Volume 14, Issue 3, pp 719–734

Psychometric validation of the child health questionnaire (CHQ) in a sample of children and adolescents with attention-deficit/hyperactivity disorder

  • Anne M. Rentz
  • Louis S. Matza
  • Kristina Secnik
  • Andrine Swensen
  • Dennis A. Revicki
Article

DOI: 10.1007/s11136-004-0832-9

Cite this article as:
Rentz, A.M., Matza, L.S., Secnik, K. et al. Qual Life Res (2005) 14: 719. doi:10.1007/s11136-004-0832-9

Abstract

Measuring health-related quality of life (HRQL) in children with attention-deficit/hyperactivity disorder (ADHD) in clinical trials can complement efficacy measures, offering a complete picture of the impact of disease and treatment on overall well-being. The purpose of the current study was to psychometrically validate a multidimensional, generic HRQL instrument completed by parents of children with ADHD. A total of 921 children and adolescents with ADHD participated in a clinical study of atomoxetine. Subjects’ parents completed the 50-item Child Health Questionnaire-Parent Version (CHQ-PF50) at baseline and week 10. ADHD symptoms and behavioral problems were assessed using parent and clinician rating scales. Internal consistency reliability at baseline was 0.88 for the CHQ-PF50 Psychosocial Summary Score, ranging from 0.53 to 0.91 for subscale scores. Construct validity was supported by statistically significant correlations between CHQ-PF50 psychosocial scores and parent and clinician symptom ratings. Several methods were used to determine clinically meaningful differences in patient outcomes: inter- and intra-patient mean CHQ-PF50 change scores were tested and standard error of measurement (SEM) and effect sizes were calculated. Study results indicate the CHQ-PF50 is reliable, valid, and responsive to change in ADHD symptoms, suggesting it may provide a means of assessing HRQL outcomes associated with treatments for ADHD.

Keywords

Attention-deficit/hyperactivity disorder (ADHD)Child health questionnaire (CHQ)Health-related quality of life (HRQL)PsychometricsResponsiveness

Abbreviations

ADHD

attention-deficit/hyperactivity disorder

ADHD-RS

attention-deficit/hyperactivity disorder rating scale-IV

ANCOVA

analysis of covariance

ANOVA

analysis of variance

CGI-ADHD-I

clinical global impressions-ADHD-improvement

CGI-ADHD-S

clinical global impressions-ADHD-Severity

CHQ

Child Health Questionnaire

CHQ-PF28

28-item Child Health Questionnaire-Parent Version

CHQ-PF50

50-item Child Health Questionnaire-Parent Version

CPRS

Conners’ parent rating scale-revised: short form

DSM-IV

diagnostic and statistical manual of mental disorders,fourth edition

HRQL

health-related quality of life

K-SADS-PL

Kiddie schedule for affective disorders and schizophrenia-present and lifetime version

SD

standard deviation

SEM

standard error of measurement

Copyright information

© Springer 2005

Authors and Affiliations

  • Anne M. Rentz
    • 1
  • Louis S. Matza
    • 1
  • Kristina Secnik
    • 2
  • Andrine Swensen
    • 2
  • Dennis A. Revicki
    • 1
  1. 1.Center for Health Outcomes ResearchMEDTAP InternationalBethesdaUSA
  2. 2.Eli Lilly and CompanyIndianapolisUSA