Prevention Science

, Volume 14, Issue 2, pp 144–156

Methods for Synthesizing Findings on Moderation Effects Across Multiple Randomized Trials

  • C. Hendricks Brown
  • Zili Sloboda
  • Fabrizio Faggiano
  • Brent Teasdale
  • Ferdinand Keller
  • Gregor Burkhart
  • Federica Vigna-Taglianti
  • George Howe
  • Katherine Masyn
  • Wei Wang
  • Bengt Muthén
  • Peggy Stephens
  • Scott Grey
  • Tatiana Perrino
  • Prevention Science and Methodology Group
Article

DOI: 10.1007/s11121-011-0207-8

Cite this article as:
Brown, C.H., Sloboda, Z., Faggiano, F. et al. Prev Sci (2013) 14: 144. doi:10.1007/s11121-011-0207-8

Abstract

This paper presents new methods for synthesizing results from subgroup and moderation analyses across different randomized trials. We demonstrate that such a synthesis generally results in additional power to detect significant moderation findings above what one would find in a single trial. Three general methods for conducting synthesis analyses are discussed, with two methods, integrative data analysis and parallel analyses, sharing a large advantage over traditional methods available in meta-analysis. We present a broad class of analytic models to examine moderation effects across trials that can be used to assess their overall effect and explain sources of heterogeneity, and present ways to disentangle differences across trials due to individual differences, contextual level differences, intervention, and trial design.

Keywords

Meta-analysisParallel data analysisIntegrative data analysisVariation in impactSubgroup analyses

Copyright information

© Society for Prevention Research 2011

Authors and Affiliations

  • C. Hendricks Brown
    • 1
  • Zili Sloboda
    • 2
  • Fabrizio Faggiano
    • 3
  • Brent Teasdale
    • 4
  • Ferdinand Keller
    • 5
  • Gregor Burkhart
    • 6
  • Federica Vigna-Taglianti
    • 7
  • George Howe
    • 8
  • Katherine Masyn
    • 9
  • Wei Wang
    • 10
  • Bengt Muthén
    • 11
  • Peggy Stephens
    • 12
  • Scott Grey
    • 13
  • Tatiana Perrino
    • 1
  • Prevention Science and Methodology Group
  1. 1.University of MiamiMiller School of MedicineMiamiUSA
  2. 2.JBS InternationalRockvilleUSA
  3. 3.Avogadro UniversityNovaraItaly
  4. 4.Georgia State UniversityAtlantaUSA
  5. 5.University of UlmUlmGermany
  6. 6.European Monitoring Centre for Drugs and Drug AddictionLisbonPortugal
  7. 7.Piedmont Centre for Drug Addiction EpidemiologyGrugliascoItaly
  8. 8.George Washington UniversityWashingtonUSA
  9. 9.Harvard UniversityCambridgeUSA
  10. 10.University of South FloridaTampaUSA
  11. 11.UCLALos AngelesUSA
  12. 12.Akron UniversityAkronUSA
  13. 13.Kent State UniversityKentUSA