Plant Molecular Biology

, Volume 69, Issue 4, pp 375-381

First online:

Cross-regulatory mechanisms in hormone signaling

  • Kavitha T. KuppusamyAffiliated withDepartment of Biology, University of Washington
  • , Cristina L. WalcherAffiliated withDepartment of Biology, University of Washington
  • , Jennifer L. NemhauserAffiliated withDepartment of Biology, University of Washington Email author 

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Recent studies suggest that hormones act through a web of interacting responses rather than through isolated linear pathways. This signal integration architecture may be one mechanism for increasing the specificity of outcomes in different cellular contexts. Several common themes for cross-regulation between pathways can be observed. Here, we propose a classification scheme for different levels of signaling pathway cross-regulation. This scheme is based on which parts of the individual pathways are acting as information conduits between pathways. Examples from the recent plant hormone biology literature are used to illustrate the different modes of interaction.


Cross-regulation Cross-talk Plant hormones Auxin Brassinosteroids Gibberellins Ethylene Jasmonates Abscisic acid