Pituitary

, Volume 14, Issue 1, pp 92–97

Atypical pituitary adenoma with malignant features

  • Adam N. Mamelak
  • John D. Carmichael
  • Patricia Park
  • Sergei Bannykh
  • Xuemo Fan
  • H. Vivien Bonert
Case Report

DOI: 10.1007/s11102-008-0151-1

Cite this article as:
Mamelak, A.N., Carmichael, J.D., Park, P. et al. Pituitary (2011) 14: 92. doi:10.1007/s11102-008-0151-1

Abstract

Pituitary carcinoma is characterized by the presence of systemic or central nervous system metastases rather than malignant histological features, making it an anomaly amongst carcinomas. In contrast, aggressive or atypical pituitary adenomas often have a relatively bland histological appearance despite their malignant growth patterns. We now report a case of a 67-years-old male with a giant pituitary tumor with overt pathologic and phenotypic features of malignancy, but the absence of metastases, that evolved from a benign non-functioning gonadotroph macroadenoma treated 10 years earlier. This case represents the first report of a pituitary adenoma with overt malignant histology that does not meet criteria for classification as pituitary carcinoma, helping to complete the pathological spectrum of disease observed with pituitary tumors.

Keywords

Pituitary Adenoma Carcinoma Malignancy Gonadotroph 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Adam N. Mamelak
    • 1
  • John D. Carmichael
    • 2
  • Patricia Park
    • 2
  • Sergei Bannykh
    • 3
  • Xuemo Fan
    • 3
  • H. Vivien Bonert
    • 2
  1. 1.Department of Neurosurgery, Pituitary CenterCedars-Sinai Medical CenterLos AngelesUSA
  2. 2.Department of EndocrinologyCedars-Sinai Medical CenterLos AngelesUSA
  3. 3.Department of PathologyCedars-Sinai Medical CenterLos AngelesUSA

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