Phytochemistry Reviews

, Volume 13, Issue 3, pp 671–694

Medicinal history of North American Veratrum

Authors

  • Christopher M. Chandler
    • Department of Chemistry and BiochemistryBoise State University
    • Department of Chemistry and BiochemistryBoise State University
Article

DOI: 10.1007/s11101-013-9328-y

Cite this article as:
Chandler, C.M. & McDougal, O.M. Phytochem Rev (2014) 13: 671. doi:10.1007/s11101-013-9328-y

Abstract

Plants belonging to the genus Veratrum have been used throughout history for their medicinal properties. During the nineteenth and twentieth centuries, phytochemical investigations revealed a host of steroidal alkaloids in Veratrum species, some of which are potent bioactives. This review discusses Veratrum species that grow in North America with a focus on the medicinal history of these plants and the steroidal alkaloids they contain. While significant reviews have been devoted to singularly describing the plant species within the genus Veratrum (botany), the staggering breadth of alkaloids isolated from these and related plants (phytochemistry), and the intricacies of how the various alkaloids act on their biological targets (physiology and biochemistry), this review will straddle the margins of the aforementioned disciplines in an attempt to provide a unified, coherent picture of the Veratrum plants of North America and the medicinal uses of their bioactive steroidal alkaloids.

Keywords

Steroidal alkaloidsBezold–Jarisch reflexHedgehog signaling pathwayHypertensionCancer

Abbreviations

USDA

United States Department of Agriculture

NRCS

National Resources Conservation Service, formerly the US Soil Conservation Service

IUPAC

International Union of Pure and Applied Chemistry

HPE

Holoprosencephalopathy, a developmental abnormality in which the prosencephalon of the embryo fails to divide into separate hemispheres causing defects in facial and brain structures

Hh

Hedgehog, used in reference to the complete series of biochemical events and structures that make up the embryonic hedgehog signaling pathway

hh

Invertebrate hedgehog gene, originally discovered in Drosophila

shh

Vertebrate Sonic hedgehog gene

ihh

Vertebrate Indian hedgehog gene

dhh

Vertebrate Desert hedgehog gene

Shh

Sonic hedgehog protein, potent morphogen coded for by shh

Shh-Np

Active Sonic hedgehog protein, 19 kDa N-terminal fragment produced by autolytic cleavage of Shh and subsequent palmitoylation of the N-terminus and addition of cholesterol to the C-terminus

Ptch

Patched, a twelve pass transmembrane transport protein integral to the hedgehog signaling pathway which serves as the binding site for the active Sonic hedgehog protein and regulates the activity of Smoothened

Smo

Smoothened, a seven transmembrane G-protein like receptor integral to the hedgehog signaling pathway; initiates the signaling cascade regulating the activity of Gli transcription factors

NBCCS

Nevoid basal cell carcinoma syndrome, an autosomal-dominant inherited condition characterized by craniofacial malformations, spina bifida, and polydactylism in addition to high rates of basal cell carcinoma and cancers of the heart, ovaries, skin, and central nervous system

BCC

Basal cell carcinoma, most common non-melanoma skin cancer; characterized by uncontrolled growth of cells in the stratum basale, the skin’s lowest layer

PNET

Primitive neuroectodermal tumor, tumors originating in cells derived from the neuroectoderm such as medulloblastomas

KAAD-cyclopamine

3-Keto N-aminoethyl aminocaproyl dihydrocin-namoyl cyclopamine, a potent hedgehog pathway antagonist derived from the natural product cyclopamine

CSC

Cancer stem cell, highly proliferative undifferentiated tumor cells, which give rise to rapidly dividing “bulk” tumor cells

Copyright information

© Springer Science+Business Media Dordrecht 2013