Phytochemistry Reviews

, Volume 13, Issue 3, pp 643–651

Medicinal herbs and antioxidants: potential of Rhinacanthus nasutus for disease treatment?

Article

DOI: 10.1007/s11101-013-9324-2

Cite this article as:
Brimson, J.M. & Tencomnao, T. Phytochem Rev (2014) 13: 643. doi:10.1007/s11101-013-9324-2

Abstract

This review covers the biological activities of the medicinal herb, Rhinacanthus nasutus, which is part of the Acanthaceae family. This herb and the compounds isolated from it have the potential to be used for the treatment of a vast array of diseases, including neurological, (such as Alzheimer’s, Parkinson’s and depression), viral and bacterial infections (such as hepatitis and herpes virus), skin disorders, and control sugar levels in diabetic patients. Many diseases involve oxidative stress, particularly neurological diseases, where oxidative stress leads to neurodegeneration. Medicinal herbs such as R. nasutus appear to be effective at protecting against such oxidative stress. Herein we discuss the potential mechanisms by which they have their antioxidant effects, and their effects on other cellular pathways, which are involved in various disease states.

Keywords

Oxidative stressReactive oxygen speciesTraditional medicineNatural products

Abbreviations

AFB1

Aflatoxin B1

HSV

Herpes simplex virus

8-OHdG

Hydroxydeoxyguanosine

iNOS

Inducible nitric oxide synthase

LPS

Lipopolysaccharide

MPO

Myeloperoxidase

NO·

Nitric oxide

PM

Plasma membrane

PGE2

Prostaglandin E2

GSH

Reduced glutathione

SOD

Superoxide dismutase

UV

Ultraviolet

VZV

Varicella-zoster virus

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Center for Excellence in Omics-Nano Medical Technology Development Project, Department of Clinical Chemistry, Faculty of Allied Health SciencesChulalongkorn UniversityBangkokThailand