Phytochemistry Reviews

, Volume 8, Issue 1, pp 283–298

Physiological effects of broccoli consumption

Article

DOI: 10.1007/s11101-008-9106-4

Cite this article as:
Jeffery, E.H. & Araya, M. Phytochem Rev (2009) 8: 283. doi:10.1007/s11101-008-9106-4

Abstract

Epidemiological studies suggest that broccoli can decrease risk for cancer. Broccoli contains many bioactives, including vitamins C and E, quercetin and kaempferol glycosides and, like other members of the Brassicaceae, several glucosinolates, including glucobrassicin (3-indolylmethyl glucosinolate) and glucoraphanin (4-methylsulphinylbutyl glucosinolate). A key bioactive component responsible for much of this activity may be sulforaphane (1-isothiocyanato-4-methylsulfinylbutane), a hydrolysis product of glucoraphanin. Sulforaphane not only upregulates a number of phase II detoxification enzymes involved in clearance of chemical carcinogens and reactive oxygen species, but has anti-tumorigenic properties, causing cell cycle arrest and apoptosis of cancer cells. The bioequivalency of sulforaphane and whole broccoli have not been fully evaluated, leaving it unclear whether whole broccoli provides a similar effect to purified sulforaphane, or whether the presence of other components in broccoli, such as indole-3-carbinol from glucobrassicin, is an added health benefit. Dietary indole-3-carbinol is known to alter estrogen metabolism, to cause cell cycle arrest and apoptosis of cancer cells and, in animals, to decrease risk for breast cancer. Recent research suggests that both dietary broccoli and the individual components sulforaphane and indole-3-carbinol may offer protection from a far broader array of diseases than cancer, including cardiovascular and neurodegenerative diseases. A common link between these oxidative degenerative diseases and cancer may be aggravation by inflammation. A small body of literature is forming suggesting that both indole-3-carbinol and sulforaphane may protect against inflammation, inhibiting cytokine production. It remains to be seen whether cancer, cardiovascular disease, dementia and other diseases of aging can all benefit from a diet rich in broccoli and other crucifers.

Keywords

BroccoliSulforaphaneAnti-inflammatoryIndole-3-carbinolAnti-carcinogenesis

Abbreviations

AhR

Aryl hydrocarbon receptor

ARE

Antioxidant response element

CNS

Central nervous system

COX-2

Cyclooxygenase-2

CYP

Cytochrome P450

DIM

Diindolyl methane

DMBA

Dimethyl benzanthracene

ERK

Extracellular signal-regulated kinase

EROD

Ethoxyresorufin O-deethylase

GCS

γ-Glutamyl cysteine synthetase

GSH

Glutathione

GST

Glutathione S-transferase

Hnqo1

Human quinone reductase 1 gene

IBD

Inflammatory bowel disease

IL-6

Interleukin 6

IL-1β

Interleukin 1 beta

iNOS

Inducible nitric oxide synthase

I3C

Indole-3-carbinol

Keap-1

Kelch-like ECH-associated protein 1

NF-κB

Nuclear factor kappa B

Nrf2

Nuclear factor E2 p45-related factor 2

PI3K

Phosphatidylinositol 3-kinase

PhIP

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

PKC

Protein kinase C

ROS

Reactive oxygen species

SF

Sulforaphane

SXR

Steroid and xenobiotic receptor

TNFα

Tumor necrosis factor alpha

TPA

Tetradecanoyl phorbol acetate

TRE

TPA response element

XRE

Xenobiotic response element

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  1. 1.University of IllinoisUrbanaUSA