Article

Phytochemistry Reviews

, Volume 7, Issue 3, pp 593-598

First online:

Design of bioreactors suitable for plant cell and tissue cultures

  • Regine EiblAffiliated withSchool of Life Sciences and Facility Management, Institute of Biotechnology, Zurich University of Applied Sciences Email author 
  • , Dieter EiblAffiliated withSchool of Life Sciences and Facility Management, Institute of Biotechnology, Zurich University of Applied Sciences

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Abstract

Plant cell suspension cultures and hairy roots are potential sources of secondary metabolites and recombinant proteins. In contrast to traditionally grown “whole wild plants” or “whole transgenic plants”, their production in bioreactors guarantees defined controlled process conditions and therefore minimizes or even prevents variations in product yield and quality, which simplifies process validation and product registration. Moreover, bioreactors and their configuration significantly affect cultivation results by accomplishing and controlling the optimum environment for effective cell growth and production of bioactive substances. This review highlights the main design criteria of the most widely used bioreactor types, both for plant cell suspension cultures and for hairy roots, and outlines suitable low-cost disposable bioreactors which have found increasing acceptance over the last 10 years.

Keywords

Disposable bioreactors Hairy roots Plant cell suspension cultures Secondary metabolites and recombinant proteins Traditional bioreactors