Eosinophilia associated with bupropion
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A 48-year-old woman started treatment with bupropion 150 mg once daily for depressive symptoms. After 19 days she presented to her family physician complaining of myalgia and non-productive cough. The physical examination was normal and laboratory investigations showed an eosinophil count of 4.7 × 109/L (0–0.5). The results of a basal test before to bupropion intake were within normal range including eosinophils (0.2 × 109/L). After ruling out other causes of eosinophilia, the physician decided to gradually discontinue bupropion, and a marked decrease in absolute eosinophil count was subsequently observed.
To the best of our knowledge, this is the third published case of bupropion-related eosinophilia. Although, in light of the case presented, the prevalence of this adverse effect seems to be low, an awareness that bupropion can be a potential cause of eosinophilia may lead to the avoidance of unnecessary diagnostic tests or referral to other specialists.
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- Eosinophilia associated with bupropion
International Journal of Clinical Pharmacy
Volume 35, Issue 4 , pp 532-534
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- 1. Basque Country Pharmacovigilance Unit, Hospital Galdakao-Usansolo, Barrio Labeaga s/n, 48960, Galdakao, Bizkaia, Spain
- 2. Department of Pharmacology, Faculty of Medicine, University of Basque Country, Leioa, Spain
- 3. Txurdinaga Health Center, Bilbao, Spain
- 4. Pharmacy Service, Araba′s Mental Health Network, Vitoria-Gasteiz, Spain