Pharmaceutical care program for type 2 diabetes patients in Brazil: a randomised controlled trial
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Background Brazilians with type 2 diabetes require action to improve haemoglobin A1C levels considering the fact that approximately 73 % of them have poor glycaemic control. Evidence has shown the potential benefits of pharmaceutical care programs in type 2 diabetes patients. Objective To evaluate the effect of a pharmaceutical care program on blood glucose, blood pressure and lipid profile in hyperglycaemic patients undergoing drug treatment for type 2 diabetes. Setting Six primary care units of the Brazilian public health system, Ouro Preto, Brazil. Method An open, randomised, controlled clinical trial was conducted for 6 months. Subjects aged 18 years or older who were using oral antidiabetic medications and presenting haemoglobin A1C levels ≥7 % were randomly assigned to receive only usual health care or usual health care plus pharmaceutical intervention. Main outcome measure Haemoglobin A1C. Results A total of 129 subjects were enrolled, and 100 patients completed the study. Compared to the control group (n = 50), the intervention group (n = 50) showed a significant reduction of haemoglobin A1C (−0.6 vs 0.7 %, p = 0.001), fasting plasma glucose, total cholesterol, LDL cholesterol, triglycerides and systolic blood pressure and a significant increase in HDL cholesterol and the use of lipid-modifying agents and platelet aggregation inhibitors. Conclusions This study suggests that a pharmaceutical care program may provide important contributions to reduce haemoglobin A1C in type 2 diabetes patients. Moreover, the promotion of the rational use of drugs may be better achieved in a context of pharmaceutical care programs in Brazil.
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- Pharmaceutical care program for type 2 diabetes patients in Brazil: a randomised controlled trial
International Journal of Clinical Pharmacy
Volume 35, Issue 1 , pp 79-86
- Cover Date
- Print ISSN
- Online ISSN
- Springer Netherlands
- Additional Links
- Diabetes mellitus
- Diabetes type 2
- Pharmaceutical care
- Randomised controlled trial
- Industry Sectors
- Author Affiliations
- 1. Post-Graduate Program in Pharmaceutical Sciences, School of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Brazil
- 2. Department of Pharmacy, School of Pharmacy, Federal University of Ouro Preto, Rua Costa Sena 171, Ouro Preto, MG, Centro 35400-000, Brazil
- 3. Department of Pharmaceutical Products, School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil
- 4. Department of Clinical Analysis, School of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Brazil