Original Paper

Pharmacy World & Science

, Volume 29, Issue 4, pp 404-411

First online:

The burden-of-illness study on osteoporosis in the Slovenian female population

  • Biljana DzajkovskaAffiliated withMillennium Pharmaceuticals, Ltd.Department of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy Email author 
  • , Albert I. WertheimerAffiliated withCenter for Pharmaceutical Health Services Research, Temple University School of Pharmacy
  • , Ales MrharAffiliated withDepartment of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy

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Study objective

This burden-of-illness study on osteoporosis was performed with the main goal to estimate the economic implications of osteoporosis for the Slovenian healthcare system.


A variety of sources was used to quantify the utilization of resources in 2003, and the appropriate unit costs were assigned to the identified resources.

Main outcome measures

The study included all direct and indirect costs that arise from treatment of osteoporosis and consequent hip, spine and wrist fractures in total Slovene postmenopausal population in 2003.


We estimated the total burden of postmenopausal osteoporosis in Slovenia for 2003 to be over SIT 7.55 billion (approximately €31.5 million); among that, 45% or SIT 3.39 billion (€14.2 million) belong to drug expenditures for osteoporosis treatment and prevention; 29% or SIT 2.2 billion (€9.2 million) include indirect costs for osteoporosis morbidity and mortality, and 26% or SIT 1.95 billion (€8.1 million) belong to direct costs for treatment, hospitalization, and rehabilitation of osteoporotic fractures. Total costs on osteoporotic fractures were however subject to an approximation due to the expert panel-based estimate of proportion of osteoporosis-caused fractures and the limited data on resource utilization for fracture treatment.


Osteoporosis is a costly disease with a significant burden to society and needs to be viewed as an important problem with a complex long-term impact.


Bone fractures Burden-of-illness Costs Economics Health policy Osteoporosis Slovenia