Pharmaceutical Research

, Volume 31, Issue 6, pp 1418–1425

Biocompatible Glycol Chitosan-Coated Gold Nanoparticles for Tumor-Targeting CT Imaging

  • In-Cheol Sun
  • Jin Hee Na
  • Seo Young Jeong
  • Dong-Eog Kim
  • Ick Chan Kwon
  • Kuiwon Choi
  • Cheol-Hee Ahn
  • Kwangmeyung Kim
Research Paper

DOI: 10.1007/s11095-013-1142-0

Cite this article as:
Sun, IC., Na, J.H., Jeong, S.Y. et al. Pharm Res (2014) 31: 1418. doi:10.1007/s11095-013-1142-0
  • 1.4k Downloads

ABSTRACT

Purpose

The application of gold nanoparticles (AuNPs) in biomedical field was limited due to the low stability in the biological condition. Herein, to enhance stability and tumor targeting ability of AuNPs, their surface was modified with biocompatible glycol chitosan (GC) and the in vivo biodistribution of GC coated AuNPs (GC-AuNPs) were studied through computed tomography (CT).

Methods

Polymer-coated gold nanoparticles were produced using GC as a reducing agent and a stabilizer. Their feasibility in biomedical application was explored through CT in tumor-bearing mice.

Results

Stability of gold nanoparticles increased in the physiological condition due to the GC coating layer on the surface. Tomographic images of tumor were successfully obtained in the tumor-xenografted animal model when the GC-AuNPs were used as a CT contrast agent. The tumor targeting property of the gold nanoparticles was due to the properties of GC because GC-AuNPs were accumulated in the tumor, while most of heparin-coated nanoparticles were found in the liver and spleen.

Conclusions

The polymer properties on the surface played an important role in the behavior of gold nanoparticles in the biological condition and the enhanced stability and tumor targeting property of nanoparticles were inherited from GC on the surface.

KEY WORDS

CT contrast agentglycol chitosangold nanoparticletumor targeting

ABBREVIATIONS

AuNPs

Gold nanoparticles

CT

Computed tomography

EDC

1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride

GC

Glycol chitosan

GC-AuNPs

Glycol chitosan coated gold nanoparticles

HEPA-AuNPs

Heparin coated gold nanoparticles

MTT

3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

NHS

N-hydroxy succinimide

PBS

Phosphate-buffered saline

TEM

Transmission electron microscopy

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • In-Cheol Sun
    • 1
  • Jin Hee Na
    • 2
  • Seo Young Jeong
    • 2
  • Dong-Eog Kim
    • 3
  • Ick Chan Kwon
    • 1
    • 4
  • Kuiwon Choi
    • 1
  • Cheol-Hee Ahn
    • 5
  • Kwangmeyung Kim
    • 1
  1. 1.Center for Theragnosis, Biomedical Research InstituteKorea Institute of Science and TechnologySeoulSouth Korea
  2. 2.Department of Life and Nanopharmaceutical SciencesKyung Hee UniversitySeoulSouth Korea
  3. 3.Department of NeurologyDongguk UniversityGoyangSouth Korea
  4. 4.KU-KIST SchoolKorea UniversitySeoulSouth Korea
  5. 5.Engineering Research Institute (ERI), Department of Materials Science and EngineeringSeoul National UniversitySeoulSouth Korea