Pharmaceutical Research

, Volume 30, Issue 11, pp 2718–2728

Superoxide Dismutase Administration, A Potential Therapy Against Oxidative Stress Related Diseases: Several Routes of Supplementation and Proposal of an Original Mechanism of Action

Authors

  • Julie Carillon
    • Nutrition & Métabolisme, UMR 204 NutriPass Prévention des Malnutritions et des Pathologies AssociéesUniversité Montpellier 1-2
  • Jean-Max Rouanet
    • Nutrition & Métabolisme, UMR 204 NutriPass Prévention des Malnutritions et des Pathologies AssociéesUniversité Montpellier 1-2
  • Jean-Paul Cristol
    • Nutrition & Métabolisme, UMR 204 NutriPass Prévention des Malnutritions et des Pathologies AssociéesUniversité Montpellier 1-2
    • Département de Biochimie Centre Hospitalier Universitaire MontpellierUniversité Montpellier 1
    • Centre CAPIO-BAYARD, Service de Cardiologie
Expert Review

DOI: 10.1007/s11095-013-1113-5

Cite this article as:
Carillon, J., Rouanet, J., Cristol, J. et al. Pharm Res (2013) 30: 2718. doi:10.1007/s11095-013-1113-5

ABSTRACT

Oxidative stress, involved in many diseases, is defined as an impaired balance between reactive oxygen species (ROS) production and antioxidant defences. Antioxidant enzymes such as superoxide dismutase (SOD) play a key role in diminishing oxidative stress. Thus, the removal of ROS by exogenous SODs could be an effective preventive strategy against various diseases. The poor bioavailability of exogenous SODs has been criticized. However, improvements in SOD formulation may overcome this limitation and boost interest in its therapeutic properties. Here, we provide a review of animal and human studies about SODs supplementation in order to evaluate their therapeutic value. Protective effects have been observed against irradiation, carcinogenesis, apoptosis and neurodegeneration. SODs administration has also been reported to alleviate inflammatory, infectious, respiratory, metabolic and cardiovascular diseases and genitourinary and fertility disorders, raising the question of its mechanism of action in these diverse situations. Some authors have shown an increase in endogenous antioxidant enzymes after exogenous SODs administration. The induction of endogenous antioxidant defence and, consequently, a decrease in oxidative stress, could explain all the effects observed. Further investigations need to be carried out to test the hypothesis that SODs supplementation acts by inducing an endogenous antioxidant defence.

KEY WORDS

bioavailabilityendogenous antioxidant defenceformulationinflammation

ABBREVIATIONS

AAPH

Hydrochloride 2,2′-azobis-2-amidinopropane

AIDS

Acquired immunodeficiency syndrome

ARE

Antioxidant response element

CAT

Catalase

Cu/Zn-SOD

Copper/zinc-superoxide dismutase

DIVEMA

Divinyl ether and maleic anhydride

DNA

Deoxyribonucleic acid

EC-SOD

Extracellular-superoxide dismutase

Fe-SOD

Iron-superoxide dismutase

FIV

Feline immunodeficiency virus

GPx

Glutathione peroxidase

H2O2

Hydrogen peroxide

HIV

Human immunodeficiency virus

HO°

Hydroxyl radical

Mn-SOD

Manganese-superoxide dismutase

Nrf2

Transcription factor nuclear-factor-E2-related factor

O2°-

Superoxide anion radical

PEG

Pegylated

PMA

Phorbol 12-myristate 13-acetate

ROS

Reactive oxygen species

SOD

Superoxide dismutase

Copyright information

© Springer Science+Business Media New York 2013