Infection-Responsive Drug Delivery from Urinary Biomaterials Controlled by a Novel Kinetic and Thermodynamic Approach
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The pH-dependent physicochemical properties of the antimicrobial quinolone, nalidixic acid, were exploited to achieve ‘intelligent’ drug release from a potential urinary catheter coating, poly(2-hydroxyethylmethacrylate) (p(HEMA)), in direct response to the elevated pH which occurs at the onset of catheter infection.
p(HEMA) hydrogels, and reduced-hydrophilicity copolymers incorporating methyl methacrylate, were loaded with nalidixic acid by a novel, surface particulate localization method, and characterized in terms of pH-dependent drug release and microbiological activity against the common urease-producing urinary pathogen Proteus mirabilis.
The pH-dependent release kinetics of surface-localized nalidixic acid were 50- and 10-fold faster at pH 9, representing the alkaline conditions induced by urease-producing urinary pathogens, compared to release at pH 5 and pH 7 respectively. Furthermore, microbiological activity against P. mirabilis was significantly enhanced after loading surface particulate nalidixic acid in comparison to p(HEMA) hydrogels conventionally loaded with dispersed drug. The more hydrophobic methyl methacrylate-containing copolymers also demonstrated this pH-responsive behavior, but additionally exhibited a sustained period of zero-order release.
The paradigm presented here provides a system with latent, immediate infection-responsive drug release followed by prolonged zero-order antimicrobial delivery, and represents an ‘intelligent’, infection-responsive, self-sterilizing biomaterial.
- Lendlein A, Pierce BF, Ambrosio L, Grijpma DW. Advanced functional polymers for medicine. Macromol Biosci. 2011;11(12):1621–4. CrossRef
- Donahoe G, King G. Estimates of medical device spending in the United States. 2011. Available from: http://new.therpmreport.com/~/media/Images/Publications/Archive/The%20Gray%20Sheet/37/29/01110718014/071811_advamed_spending_report.pdf.
- Francolini I, Donelli G. Prevention and control of biofilm-based medical-device-related infections. FEMS Immunol Med Microbiol. 2010;59(3):227–38.
- Nicolle LE. Catheter-acquired urinary tract infection: the once and future guidelines. Infect Control Hosp Epidemiol. 2010;31(4):327–9. CrossRef
- Scott RD. The direct medical costs of healthcare-associated infections in U.S. hospitals and the benefits of prevention. 2009. Available from: http://www.cdc.gov/HAI/pdfs/hai/Scott_CostPaper.pdf.
- Stickler D. Bacterial biofilms in patients with indwelling urinary catheters. Nat Clin Pract Urol. 2008;5(11):598–608. CrossRef
- Saint S, Meddings JA, Calfee D, Kowalski CP, Krein SL. Catheter-associated urinary tract infection and the Medicare rule changes. Ann Intern Med. 2009;150(12):877–84.
- ZoBell CE. The effect of solid surfaces upon bacterial activity. J Bacteriol. 1943;46(1):39–56.
- Andersen TE, Kingshott P, Palarasah Y, Benter M, Alei M, Kolmos HJ. A flow chamber assay for quantitative evaluation of bacterial surface colonization used to investigate the influence of temperature and surface hydrophilicity on the biofilm forming capacity of uropathogenic Escherichia coli. J Microbiol Methods. 2010;81(2):135–40. CrossRef
- Hall-Stoodley L, Stoodley P. Evolving concepts in biofilm infections. Cell Microbiol. 2009;11(7):1034–43. CrossRef
- Stickler DJ. The encrustation and blockage of long-term indwelling bladder catheters: a way forward in prevention and control. Spinal Cord. 2010;48(11):784–90. CrossRef
- Stickler DJ. Modulation of crystalline Proteus mirabilis biofilm development on urinary catheters. J Med Microbiol. 2006;55(5):489–94. CrossRef
- Lin H, Ou L, Lin Y, Ling M. Hollow, pH-sensitive calcium-alginate/poly(acrylic acid) hydrogel beads as drug carriers for vancomycin release. J Appl Polym Sci. 2010;118(4):1878–86.
- McCoy C, Brady C, Cowley J, McGlinchey S, McGoldrick N, Kinnear D. Triggered drug delivery from biomaterials. Expert Opin Drug Deliv. 2010;7(5):605–16. CrossRef
- Nowatzki PJ, Koepsel RR, Stoodley P, Min K, Harper A, Murata H, et al. Salicylic acid-releasing polyurethane acrylate polymers as anti-biofilm urological catheter coatings. Acta Biomater. 2012;8(5):1869–80. CrossRef
- Ross DL. Aqueous solubilities of some variously substituted quinolone antimicrobials. Int J Pharm. 1990;63(3):237–50. CrossRef
- Jones D, Lorimer C, Mccoy C, Gorman S. Characterization of the physicochemical, antimicrobial, and drug release properties of thermoresponsive hydrogel copolymers designed for medical device applications. J Biomed Mater Res B Appl Biomater. 2008;85B(2):417–26. CrossRef
- Koller CN. Characterization of the pH-mediated solubility of Bacillus thuringiensis var. san diego native [delta]-endotoxin crystals. Biochem Biophys Res Commun. 1992;184(2):692–9. CrossRef
- Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm. 1983;15(1):25–35. CrossRef
- Fuertes I. Study of critical points of drugs with different solubilities in hydrophilic matrices. Int J Pharm. 2010;383(1–2):138–46. CrossRef
- Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966;45(4):493–6.
- Tiwari MM, Charlton ME, Anderson JR, Hermsen ED, Rupp ME. Inappropriate use of urinary catheters: a prospective observational study. Am J Infect Control. 2012;40(1):51–4. CrossRef
- Garibaldi RA, Burke JP, Dickman ML, Smith CB. Factors predisposing to bacteriuria during indwelling urethral catheterization. N Engl J Med. 1974;291(5):215–9. CrossRef
- Pinto S, Alves P, Matos C, Santos A, Rodrigues L, Teixeira J. Poly(dimethyl siloxane) surface modification by low pressure plasma to improve its characteristics towards biomedical applications. Colloids Surf B Biointerfaces. 2010;81(1):20–6. CrossRef
- Zilberman M, Elsner J. Antibiotic-eluting medical devices for various applications. J Control Release. 2008;130(3):202–15. CrossRef
- Monteiro D, Gorup L, Takamiya A, Ruvollo A, Camargo E, Barbosa D. The growing importance of materials that prevent microbial adhesion: antimicrobial effect of medical devices containing silver. Int J Antimicrob Agents. 2009;34(2):103–10. CrossRef
- Huynh T, Padois K, Sonvico F, Rossi A, Zani F, Pirot F. Characterization of a polyurethane-based controlled release system for local delivery of chlorhexidine diacetate. Eur J Pharm Biopharm. 2010;74(2):255–64. CrossRef
- Basak P, Adhikari B, Banerjee I, Maiti T. Sustained release of antibiotic from polyurethane coated implant materials. J Mater Sci Mater Med. 2009;20(s1):213–21. CrossRef
- Campoccia D, Montanaro L, Speziale P, Arciola C. Antibiotic-loaded biomaterials and the risks for the spread of antibiotic resistance following their prophylactic and therapeutic clinical use. Biomaterials. 2010;31(25):6363–77. CrossRef
- Johnson JR, Kuskowski MA, Wilt TJ. Systematic review: Antimicrobial urinary catheters to prevent catheter-associated urinary tract infection in hospitalized patients. Ann Intern Med. 2006;144(2):116–26.
- Jahren S, Butler M, Adams S, Cameron R. Swelling and viscoelastic characterisation of pH-responsive chitosan hydrogels for targeted drug delivery. Macromol Chem Phys. 2010;211(6):644–50. CrossRef
- Babic S. Determination of pKa values of active pharmaceutical ingredients. TrAC Trends Anal Chem. 2007;26(11):1043–61. CrossRef
- Moore WE. Biopharmaceutical investigation of nalidixic acid in man. J Pharm Sci. 1965;54(1):36–41. CrossRef
- Andersson MI. Development of the quinolones. J Antimicrob Chemother. 2003;51(S1):1–11. CrossRef
- Lauridsen M, Hansen SH, Jaroszewski JW, Cornett C. Human urine as test material in H-1 NMR-based metabonomics: recommendations for sample preparation and storage. Anal Chem. 2007;79(3):1181–6. CrossRef
- Osberg I, Chase HP, Garg SK, Deandrea A, Harris S, Hamilton R, et al. Effects of storage time and temperature on measurement of small concentrations of albumin in urine. Clin Chem. 1990;36(8):1428–30.
- Lin CC. Hydrogels in controlled release formulations: network design and mathematical modeling. Adv Drug Deliv Rev. 2006;58(12–13):1379. CrossRef
- Hoare TR. Hydrogels in drug delivery: progress and challenges. Polymer. 2008;49(8):1993–2007. CrossRef
- Infection-Responsive Drug Delivery from Urinary Biomaterials Controlled by a Novel Kinetic and Thermodynamic Approach
Volume 30, Issue 3 , pp 857-865
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