Nanochannel Technology for Constant Delivery of Chemotherapeutics: Beyond Metronomic Administration
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The purpose of this study is to demonstrate the long-term, controlled, zero-order release of low- and high-molecular weight chemotherapeutics through nanochannel membranes by exploiting the molecule-to-surface interactions presented by nanoconfinement.
Silicon membranes were produced with nanochannels of 5, 13 and 20 nm using standardized industrial microfabrication techniques. The study of the diffusion kinetics of interferonα-2b and leuprolide was performed by employing UV diffusion chambers. The released amount in the sink reservoir was monitored by UV absorbance.
Continuous zero-order release was demonstrated for interferonα-2b and leuprolide at release rates of 20 and 100 μg/day, respectively. The release rates exhibited by these membranes were verified to be in ranges suitable for human therapeutic applications.
Our membranes potentially represent a viable nanotechnological approach for the controlled administration of chemotherapeutics intended to improve the therapeutic efficacy of treatment and reduce many of the side effects associated with conventional drug administration.
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- Nanochannel Technology for Constant Delivery of Chemotherapeutics: Beyond Metronomic Administration
Volume 28, Issue 2 , pp 292-300
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- controlled release
- drug delivery
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- Author Affiliations
- 1. Department of NanoMedicine and Biomedical Engineering (nBME), The University of Texas Medical School at Houston, Houston, Texas, USA
- 2. NanoMedical Systems, Inc., Austin, Texas, USA
- 3. Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
- 4. Department of Bioengineering, Rice University, Houston, Texas, USA
- 5. 1825 Pressler St. Suite 537, Houston, Texas, 77030, USA