Pharmaceutical Research

, Volume 27, Issue 6, pp 962–978

Apigenin: A Promising Molecule for Cancer Prevention

Authors

  • Sanjeev Shukla
    • Departments of Urology & NutritionCase Western Reserve University
    • Department of UrologyUniversity Hospitals Case Medical Center
    • Departments of Urology & NutritionCase Western Reserve University
    • Department of UrologyUniversity Hospitals Case Medical Center
    • Division of General Medical SciencesCase Comprehensive Cancer Center
Expert Review

DOI: 10.1007/s11095-010-0089-7

Cite this article as:
Shukla, S. & Gupta, S. Pharm Res (2010) 27: 962. doi:10.1007/s11095-010-0089-7

ABSTRACT

Apigenin, a naturally occurring plant flavone, abundantly present in common fruits and vegetables, is recognized as a bioactive flavonoid shown to possess anti-inflammatory, antioxidant and anticancer properties. Epidemiologic studies suggest that a diet rich in flavones is related to a decreased risk of certain cancers, particularly cancers of the breast, digestive tract, skin, prostate and certain hematological malignancies. It has been suggested that apigenin may be protective in other diseases that are affected by oxidative process, such as cardiovascular and neurological disorders, although more research needs to be conducted in this regard. Human clinical trials examining the effect of supplementation of apigenin on disease prevention have not been conducted, although there is considerable potential for apigenin to be developed as a cancer chemopreventive agent.

KEY WORDS

apigeninapoptosiscell cyclechemopreventionflavonoids

ABBREVIATIONS

Apaf-1

apoptotic protease activating factor 1

AR

androgen receptor

CK

casein kinase

DFF

DNA fragmentation factor

EGFR

epidermal growth factor receptor

ER

estrogen receptor

ERK

extracellular signal-activated kinase

HIF

hypoxia-inducible factor

Id

Inhibitor of differentiation or DNA binding protein

IGF

insulin-like growth factor

IGFBP

insulin-like growth factor binding protein

LPS

lipopolysaccharide

MAPK

mitogen-activated protein kinase

MLL

mixed lineage leukemia

NF-κB

nuclear factor-kappaB

ODC

ornithine decarboxylase

PARP

poly (ADP-ribose) polymerase

PI3K

phosphatidylinositol 3-kinase

PMA

phorbol 12-myristate 13-acetate

Rb

retinoblastoma

SOD

superoxide dismutase

TNF

tumor necrosis factor

UV

ultraviolet

VEGF

vascular endothelial growth factor

Copyright information

© Springer Science+Business Media, LLC 2010