, Volume 27, Issue 5, pp 739-749
Date: 11 Mar 2010

In-Silico Approaches to Multi-target Drug Discovery

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Abstract

Multi-target drugs against selective multiple targets improve therapeutic efficacy, safety and resistance profiles by collective regulations of a primary therapeutic target together with compensatory elements and resistance activities. Efforts have been made to employ in-silico methods for facilitating the search and design of selective multi-target agents. These methods have shown promising potential in facilitating drug discovery directed at selective multiple targets.