Pharmaceutical Research

, Volume 26, Issue 4, pp 958–964

Effect of Atorvastatin Versus Rosuvastatin on Levels of Serum Lipids, Inflammatory Markers and Adiponectin in Patients with Hypercholesterolemia

  • Hai-yan Qu
  • Ya-wei Xiao
  • Gui-hua Jiang
  • Zhi-yun Wang
  • Yun Zhang
  • Mei Zhang
Research Paper

DOI: 10.1007/s11095-008-9798-6

Cite this article as:
Qu, H., Xiao, Y., Jiang, G. et al. Pharm Res (2009) 26: 958. doi:10.1007/s11095-008-9798-6

Abstract

Purpose

To compare the short-term effect of treatment with atorvastatin and rosuvastatin on levels of serum lipids, inflammatory markers and adiponectin in patients with hypercholesterolemia.

Methods

Sixty-nine patients with hypercholesterolemia were randomly assigned to receive 10 mg/day of atorvastatin or rosuvastatin for 12 weeks. Inflammatory biomarkers, including highsensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF)-alpha, matrix metalloproteinase-9 (MMP-9), and endothelin (ET-1), plasminogen activator inhibitor type 1 (PAI-1) and plasma tissue plasminogen activator (tPA), adiponectin, and lipid profiles were measured before and after statin therapy.

Results

Atorvastatin and rosuvastatin both lowered levels of hs-CRP, MMP-9, PAI-1, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) from baseline values, with rosuvastatin lowering TC and LDL-C to a greater extent than atorvastatin (P < 0.05). Adiponectin level increase was 15% higher than that at baseline with atorvastatin (P > 0.05) but 67% higher with rosuvastatin (P < 0.05).

Conclusions

Therapy with both statins not only significantly improved lipid profiles but also decreased levels of vascular biomarkers hs-CRP, MMP-9, and PAI-1; however, only rosuvastatin increased serum adiponectin levels significantly in patients with hypercholesterolemia, which could imply a beneficial effect in coronary artery disease.

KEY WORDS

atorvastatinendotheliumhypercholesterolemiarosuvastatinserum adiponectin

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Hai-yan Qu
    • 1
    • 2
  • Ya-wei Xiao
    • 1
  • Gui-hua Jiang
    • 1
  • Zhi-yun Wang
    • 1
  • Yun Zhang
    • 1
  • Mei Zhang
    • 1
  1. 1.The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public HealthShandong University Qilu HospitalJinanPeople’s Republic of China
  2. 2.Department of CardiologyShandong Provincial Chest HospitalJinanPeople’s Republic of China