Pharmaceutical Chemistry Journal

, Volume 46, Issue 11, pp 667–671

Synthesis and antimicrobial activity of sulfide and sulfone derivatives of 4-(2-chloro-4-fluorophenyl)-1,3-thiazol-2-amine/acetamide

  • N. P. Badiger
  • J. S. Mulla
  • Iqbal Khazi
  • I. M. Khazi
Article

DOI: 10.1007/s11094-013-0866-9

Cite this article as:
Badiger, N.P., Mulla, J.S., Khazi, I. et al. Pharm Chem J (2013) 46: 667. doi:10.1007/s11094-013-0866-9

A series of 4-(2-chloro-4-fluorophenyl)-5-(4-substituted phenylsulfanyl)-thiazole-2-ylamines/acetamides (3a – 5b) and 5-(4-substituted benzenesulfonyl)-4-(2-chloro-4-fluorophenyl)-thiazole-2-ylamines/acetamides (6a – 8b) derivatives have been synthesized. The title compounds (3a – 5b) were obtained by the nucleophilic substitution of bromo derivatives (2a – 2b) with various substituted thiophenols. Structures of all the newly synthesized compounds were established by analytical and spectral data. The synthesized compounds have been screened for their antimicrobial activity against Gram-negative (Escherichia coli) and Gram-positive (methicillin resistant Staphylococcus aureus) bacteria and Aspergillus niger and Candida albicans fungi.

Keywords

Thiazole sulfides sulfones antimicrobial activity 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • N. P. Badiger
    • 1
    • 2
  • J. S. Mulla
    • 1
  • Iqbal Khazi
    • 1
  • I. M. Khazi
    • 1
  1. 1.Department of ChemistryKarnatak UniversityDharwadIndia
  2. 2.Department of Chemistry S.D.M. College of Engineering & TechnologyDharwadIndia

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