Pharmaceutical Chemistry Journal

, Volume 45, Issue 7, pp 419–422

An improved synthesis of N-(3-phenylbicyclo[2.2.1]-yl)-N-ethylamine hydrochloride (Fencamfamine)

  • I. A. Novakov
  • B. S. Orlinson
  • R. V. Brunilin
  • M. B. Navrotskii
  • A. S. Eremiichuk
  • S. A. Dumler
  • E. A. Gordeeva
Article

DOI: 10.1007/s11094-011-0646-3

Cite this article as:
Novakov, I.A., Orlinson, B.S., Brunilin, R.V. et al. Pharm Chem J (2011) 45: 419. doi:10.1007/s11094-011-0646-3

We describe here a new and efficient method for synthesis of N-(3-phenyl[2.2.1]bicyclohept-2-yl)-N-ethylamine hydrochloride (Fencamfamine), based on the reduction of trans-5-nitro-6-phenylbicyclo[2.2.1]hept-2-ene with Raney alloy mixed with aqueous NaOH and tetrahydrofuran followed by N-alkylation of the resulting product with 95% ethanol in the presence of skeletal nickel.

Key words

N-(3-phenyl[2.2.1]bicyclohept-2-yl)-N-ethylamine hydrochloride Fencamfamine 

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • I. A. Novakov
    • 1
  • B. S. Orlinson
    • 1
  • R. V. Brunilin
    • 1
  • M. B. Navrotskii
    • 1
  • A. S. Eremiichuk
    • 1
  • S. A. Dumler
    • 1
  • E. A. Gordeeva
    • 1
  1. 1.VolgogradRussia

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