An improved synthesis of N-(3-phenylbicyclo[2.2.1]-yl)-N-ethylamine hydrochloride (Fencamfamine)
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- Novakov, I.A., Orlinson, B.S., Brunilin, R.V. et al. Pharm Chem J (2011) 45: 419. doi:10.1007/s11094-011-0646-3
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We describe here a new and efficient method for synthesis of N-(3-phenyl[2.2.1]bicyclohept-2-yl)-N-ethylamine hydrochloride (Fencamfamine), based on the reduction of trans-5-nitro-6-phenylbicyclo[2.2.1]hept-2-ene with Raney alloy mixed with aqueous NaOH and tetrahydrofuran followed by N-alkylation of the resulting product with 95% ethanol in the presence of skeletal nickel.