Targeted search for a lead compound in a series of cinnamic acid derivatives possessing antiradical activity
- First Online:
- Cite this article as:
- Agadzhanyan, V.S., Oganesyan, E.T. & Abaev, V.T. Pharm Chem J (2010) 44: 360. doi:10.1007/s11094-010-0468-8
- 113 Downloads
Indices of reactivity with respect to active oxygen species that resulted from quantum-chemical calculations (PM3 and AM1) have been studied in a series of hydroxyl-and methoxy-derivatives of cinnamic acid. The high antioxidant activity of 4-hydroxy-3,5-di-tert-butylcinnamic acid has been predicted and then experimentally confirmed, which can be of interest for the creation of new drugs.