Inverse agonists of H1-receptors as promising antiallergy agents (a review)
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- Gushchin, I.S. Pharm Chem J (2010) 44: 1. doi:10.1007/s11094-010-0386-9
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The review summarizes published data and presents original results that illustrate the variety of antiallergic properties of second generation antihistamine drugs. General notions of inverse agonists of H1-receptors and features of the receptor–ligand interaction that maintain H1-receptors in the non-active state are considered. The broadening of clinical indications for the administration of inverse agonists of H1-receptors aimed at preventing the exacerbation of allergic (atopic) disorders and inhibiting allergic inflammation processes is justified.