, Volume 44, Issue 1, pp 1-6
Date: 20 May 2010

Inverse agonists of H1-receptors as promising antiallergy agents (a review)

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The review summarizes published data and presents original results that illustrate the variety of antiallergic properties of second generation antihistamine drugs. General notions of inverse agonists of H1-receptors and features of the receptor–ligand interaction that maintain H1-receptors in the non-active state are considered. The broadening of clinical indications for the administration of inverse agonists of H1-receptors aimed at preventing the exacerbation of allergic (atopic) disorders and inhibiting allergic inflammation processes is justified.

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 1, pp.3–8, January, 2010.