Pharmaceutical Chemistry Journal

, Volume 44, Issue 1, pp 1–6

Inverse agonists of H1-receptors as promising antiallergy agents (a review)


  • I. S. Gushchin
    • Institute of Immunology, Federal Medico-Biological AgencyMinistry of Public Health and Social Development of the Russian Federation
Molecular-biological problems of drug design and mechanism of drug action

DOI: 10.1007/s11094-010-0386-9

Cite this article as:
Gushchin, I.S. Pharm Chem J (2010) 44: 1. doi:10.1007/s11094-010-0386-9

The review summarizes published data and presents original results that illustrate the variety of antiallergic properties of second generation antihistamine drugs. General notions of inverse agonists of H1-receptors and features of the receptor–ligand interaction that maintain H1-receptors in the non-active state are considered. The broadening of clinical indications for the administration of inverse agonists of H1-receptors aimed at preventing the exacerbation of allergic (atopic) disorders and inhibiting allergic inflammation processes is justified.

Key words

second generation H1-antihistamine drugsH1-receptorsinverse agonistsNF-κBantiallergic effect

Copyright information

© Springer Science+Business Media, Inc. 2010