, Volume 42, Issue 6, pp 363-367

Radiation sterilization of medicinal formulations of doxorubicin bound to poly(butylcyanoacrylate) nanoparticles

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Abstract

Polybutylcyanoacrylate nanoparticles represent a potential system for delivering medicinal agents. The present report describes development of a method for radiation sterilization of medicinal formulations of doxorubicin based on polybutylcyanoacrylate nanoparticles. The physicochemical properties of the medicinal formulation were studied after gamma irradiation and irradiation with accelerated electrons over the dose range 10–35 kGy. The chemical structure of doxorubicin and the polymer carrier was found to be intact after irradiation at a dose of 25 kGy. Irradiation at these doses also had no effect on the colloidal properties of polymer nanoparticles, which retained their stability to aggregation and sedimentation. The optimum sterilizing dose was 15 kGy.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 6, pp. 52–56, June, 2008.