, Volume 15, Issue 1, pp 119-136

Dynamic programming approach to the numerical solution of optimal control with paradigm by a mathematical model for drug therapies of HIV/AIDS

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Abstract

In this paper, we present a new numerical algorithm to find the optimal control for the general nonlinear lumped systems without state constraints. The dynamic programming-viscosity solution (DPVS) approach is developed and the numerical solutions of both approximate optimal control and trajectory are produced. To show the effectiveness and efficiency of new algorithm, we apply it to an optimal control problem of two types of drug therapies for human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS). The quality of the obtained optimal control and the trajectory pair is checked through comparison with the costs under the arbitrarily selected different controls. The results illustrate the effectiveness of the algorithm.

This work was supported by the National Natural Science Foundation of China (11001012, 61273129, 11171011), the National Basic Research Program of China (2011CB808002), the Natural Science Foundation of Beijing (1102010), and the National Research Foundation of South Africa.