Neuropsychology Review

, Volume 22, Issue 2, pp 154–169

Function and Dysfunction of Prefrontal Brain Circuitry in Alcoholic Korsakoff’s Syndrome


DOI: 10.1007/s11065-012-9198-x

Cite this article as:
Oscar-Berman, M. Neuropsychol Rev (2012) 22: 154. doi:10.1007/s11065-012-9198-x


The signature symptom of alcohol-induced persisting amnestic disorder, more commonly referred to as alcoholic Korsakoff’s syndrome (KS), is anterograde amnesia, or memory loss for recent events, and until the mid 20th Century, the putative brain damage was considered to be in diencephalic and medial temporal lobe structures. Overall intelligence, as measured by standardized IQ tests, usually remains intact. Preservation of IQ occurs because memories formed before the onset of prolonged heavy drinking—the types of information and abilities tapped by intelligence tests—remain relatively well preserved compared with memories recently acquired. However, clinical and experimental evidence has shown that neurobehavioral dysfunction in alcoholic patients with KS does include nonmnemonic abilities, and further brain damage involves extensive frontal and limbic circuitries. Among the abnormalities are confabulation, disruption of elements of executive functioning and cognitive control, and emotional impairments. Here, we discuss the relationship between neurobehavioral impairments in KS and alcoholism-related brain damage. More specifically, we examine the role of damage to prefrontal brain systems in the neuropsychological profile of alcoholic KS.


AlcoholismKorsakoff’s syndromeFrontal brain circuitryExecutive functionsEmotion

Copyright information

© Springer Science+Business Media, LLC (outside the USA) 2012

Authors and Affiliations

  1. 1.Department of Neurology and Division of PsychiatryBoston University School of MedicineBostonUSA
  2. 2.Department of Anatomy & NeurobiologyBoston University School of MedicineBostonUSA
  3. 3.Psychology Research Service, Department of Veterans Affairs Medical CenterBostonUSA
  4. 4.Laboratory of Neuropsychology, L-815Boston University School of MedicineBostonUSA