Neuropsychology Review

, Volume 22, Issue 3, pp 298–309

Family History and APOE-4 Genetic Risk in Alzheimer’s Disease

  • Markus Donix
  • Gary W. Small
  • Susan Y. Bookheimer

DOI: 10.1007/s11065-012-9193-2

Cite this article as:
Donix, M., Small, G.W. & Bookheimer, S.Y. Neuropsychol Rev (2012) 22: 298. doi:10.1007/s11065-012-9193-2


Identifying risk factors for Alzheimer’s disease, such as carrying the APOE-4 allele, and understanding their contributions to disease pathophysiology or clinical presentation is critical for establishing and improving diagnostic and therapeutic strategies. A first-degree family history of Alzheimer’s disease represents a composite risk factor, which reflects the influence of known and unknown susceptibility genes and perhaps non-genetic risks. There is emerging evidence that investigating family history risk associated effects may contribute to advances in Alzheimer’s disease research and ultimately clinical practice.


Alzheimer’s diseaseAPOE GenotypeFamily historyGenetic riskRisk factorsNeuroimaging

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Markus Donix
    • 1
    • 2
  • Gary W. Small
    • 4
    • 6
  • Susan Y. Bookheimer
    • 3
    • 4
    • 5
  1. 1.Department of Psychiatry and PsychotherapyUniversitätsklinikum Carl Gustav Carus, Technische Universität DresdenDresdenGermany
  2. 2.DZNE, German Center for Neurodegenerative DiseasesDresdenGermany
  3. 3.David Geffen School of Medicine at UCLA, Center for Cognitive NeurosciencesSemel InstituteLos AngelesUSA
  4. 4.David Geffen School of Medicine at UCLA, Department of Psychiatry and Biobehavioral SciencesSemel InstituteLos AngelesUSA
  5. 5.Department of PsychologyDavid Geffen School of Medicine at UCLALos AngelesUSA
  6. 6.UCLA Longevity CenterLos AngelesUSA