Family History and APOE-4 Genetic Risk in Alzheimer’s Disease
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- Donix, M., Small, G.W. & Bookheimer, S.Y. Neuropsychol Rev (2012) 22: 298. doi:10.1007/s11065-012-9193-2
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Identifying risk factors for Alzheimer’s disease, such as carrying the APOE-4 allele, and understanding their contributions to disease pathophysiology or clinical presentation is critical for establishing and improving diagnostic and therapeutic strategies. A first-degree family history of Alzheimer’s disease represents a composite risk factor, which reflects the influence of known and unknown susceptibility genes and perhaps non-genetic risks. There is emerging evidence that investigating family history risk associated effects may contribute to advances in Alzheimer’s disease research and ultimately clinical practice.