Reply to Letter of Peter Good
- Martha R. Herbert
- … show all 1 hide
Authors Helt, Kelley, Boorstein, Pandey, and Fein, asked authors Kinsbourne and Herbert to respond to the Good letter because of their expertise in this area. Following is Dr. Herbert's response.
The most remarkable thing about fever-associated transient improvement of core features of autism (Curran et al. 2007) is the challenge it poses to the conception of autism as trait, as static encephalopathy (Herbert 2009). What neurobiological mechanisms might underlie autism as dynamic encephalopathy? Others have advanced various models; Good proposes that in the setting of fever the free amino acid taurine may reduce astrocytic enlargement and capillary compression, thereby improving brain blood flow, and may account for clinical improvement in this context. He also proposes that ASD individuals who do not respond in this way may be taurine deficient.
One problem with pinning an explanation on any one mechanism or agent, such as taurine, is the pleiotropic web of influences of the components ...
- Albinana, E, Sacristan, S, Martin Del Rio, R, Solis, JM, Hernandez-Guijo, JM (2010) Modulation of calcium channels by taurine acting via a metabotropic-like glycine receptor. Cellular and Molecular Neurobiology 30: pp. 1225-1233 CrossRef
- Blaylock, RL, Strunecka, A (2009) Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders. Current Medicinal Chemistry 16: pp. 157-170 CrossRef
- Chauhan, A, Chauhan, V, Brown, T eds. (2009) Autism: Oxidative stress, inflammation and immune abnormalities. Taylor & Francis/CRC, Boca Raton
- Curran, LK, Newschaffer, CJ, Lee, LC, Crawford, SO, Johnston, MV, Zimmerman, AW (2007) Behaviors associated with fever in children with autism spectrum disorders. Pediatrics 120: pp. e1386-1392 CrossRef
- El Idrissi, A, Trenkner, E (2003) Taurine regulates mitochondrial calcium homeostasis. Advances in Experimental Medicine and Biology 526: pp. 527-536
- El Idrissi, A, Messing, J, Scalia, J, Trenkner, E (2003) Prevention of epileptic seizures by taurine. Advances in Experimental Medicine and Biology 526: pp. 515-525
- Harada, M., Taki, M. M., Nose, A., Kubo, H., Mori, K., Nishitani, H., et al. (2010). Non-invasive evaluation of the GABAergic/glutamatergic system in autistic patients observed by MEGA-editing proton MR spectroscopy using a clinical 3 Tesla instrument. Journal of Autism and Development Disorders.
- Herbert, M. R. (2009). Autism: The centrality of active pathophysiology and the shift from static to chronic dynamic encephalopathy. Taylor & Francis/CRC Press.
- James, SJ, Melnyk, S, Jernigan, S, Cleves, MA, Halsted, CH, Wong, DH, Gaylor, DW (2006) Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics 141B: pp. 947-956 CrossRef
- Kirchner, A, Breustedt, J, Rosche, B, Heinemann, UF, Schmieden, V (2003) Effects of taurine and glycine on epileptiform activity induced by removal of Mg2+ in combined rat entorhinal cortex-hippocampal slices. Epilepsia 44: pp. 1145-1152 CrossRef
- Molchanova, SM, Oja, SS, Saransaari, P (2007) Effect of taurine on the concentrations of glutamate, GABA, glutamine and alanine in the rat striatum and hippocampus. Proceedings of the Western Pharmacology Society 50: pp. 95-97
- Oliveira, MW, Minotto, JB, Oliveira, MR, Zanotto-Filho, A, Behr, GA, Rocha, RF, Klamt, F (2010) Scavenging and antioxidant potential of physiological taurine concentrations against different reactive oxygen/nitrogen species. Pharmacological Reports 62: pp. 185-193
- Pessah, I. N. & Lein, P. J. (2008). Evidence for Environmental Susceptibility in Autism: What We Need to Know About Gene x Environment Interactions: Humana.
- Rubenstein, JL, Merzenich, MM (2003) Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes, Brain, and Behavior 2: pp. 255-267 CrossRef
- Yu, SS, Wang, M, Li, XM, Chen, WH, Chen, JT, Wang, HL, Ruan, DY (2007) Influences of different developmental periods of taurine supplements on synaptic plasticity in hippocampal CA1 area of rats following prenatal and perinatal lead exposure. BMC Developmental Biology 7: pp. 51 CrossRef
- Zhu, DM, Wang, M, She, JQ, Yu, K, Ruan, DY (2005) Protection by a taurine supplemented diet from lead-induced deficits of long-term potentiation/depotentiation in dentate gyrus of rats in vivo. Neuroscience 134: pp. 215-224 CrossRef
- Reply to Letter of Peter Good
Volume 21, Issue 1 , pp 70-71
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Industry Sectors
- Author Affiliations
- 1. TRANSCEND Research Program, Pediatric Neurology, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 10.018, Charlestown, MA, 02129, USA