Neuropsychology Review

, Volume 20, Issue 4, pp 362–375

Development of the Brain’s Functional Network Architecture

  • Alecia C. Vogel
  • Jonathan D. Power
  • Steven E. Petersen
  • Bradley L. Schlaggar
Review

DOI: 10.1007/s11065-010-9145-7

Cite this article as:
Vogel, A.C., Power, J.D., Petersen, S.E. et al. Neuropsychol Rev (2010) 20: 362. doi:10.1007/s11065-010-9145-7

Abstract

A full understanding of the development of the brain’s functional network architecture requires not only an understanding of developmental changes in neural processing in individual brain regions but also an understanding of changes in inter-regional interactions. Resting state functional connectivity MRI (rs-fcMRI) is increasingly being used to study functional interactions between brain regions in both adults and children. We briefly review methods used to study functional interactions and networks with rs-fcMRI and how these methods have been used to define developmental changes in network functional connectivity. The developmental rs-fcMRI studies to date have found two general properties. First, regional interactions change from being predominately anatomically local in children to interactions spanning longer cortical distances in young adults. Second, this developmental change in functional connectivity occurs, in general, via mechanisms of segregation of local regions and integration of distant regions into disparate subnetworks.

Keywords

Functional connectivityGraph theoryfMRISegregationIntegration

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Alecia C. Vogel
    • 1
  • Jonathan D. Power
    • 1
  • Steven E. Petersen
    • 1
    • 2
    • 3
    • 5
  • Bradley L. Schlaggar
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of NeurologyWashington University School of MedicineSt. LouisUSA
  2. 2.Department of RadiologyWashington University School of MedicineSt. LouisUSA
  3. 3.Department of Anatomy and NeurobiologyWashington University School of MedicineSt. LouisUSA
  4. 4.Department of PediatricsWashington University School of MedicineSt. LouisUSA
  5. 5.Department of PsychologyWashington University in St. LouisSt. LouisUSA