The Neuropsychology of Schizophrenia Circa 2009
- Robert M. Bilder
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The last 30 years have been marked by the emergence of transformative technologies for the study of brain structure-function relations, and these have been deployed vigorously to help unravel the mysterious causes for, and treatments for the schizophrenia syndrome. Despite the progress, the ultimate goal—to identify a “smoking gun,” in the form of a cognitive, a functional anatomical or a genetic signature responsible for the brain pathology underlying schizophrenia—remains elusive. This collection of articles from global leaders in neuropsychological research on schizophrenia makes poignant how much our thinking has changed over the last three decades, but also that we still have more questions than answers about the fundamental neurobiological underpinnings of schizophrenia.
To put the progress in perspective, we may recall the conclusions of Heaton et al. (1978), following their incisive review of neuropsychological studies of psychiatric disorders: “The finding that chronic or proces
“The finding that chronic or proces
- Bilder, R. M., Poldrack, R., Parker, D. S., Reise, S. P., Jentsch, J. D., Cannon, T., et al. (2009a). Cognitive phenomics. In S. Wood, N. Allen & C. Pantelis (Eds.), Handbook of neuropsychology of mental disorders. London: Oxford University Press.
- Bilder, R. M., Sabb, F. W., Cannon, T. D., London, E. D., Jentsch, J. D., Parker, D. S., et al. (2009b). Phenomics: the systematic study of phenotypes on a genome-wide scale. Neuroscience.
- Bilder, R. M., Sabb, F. W., Parker, D. S., Kalar, D., Chu, W. W., Fox, J., et al. (2009c). Cognitive ontologies for neuropsychiatric phenomics research. Cognitive Neuropsychiatry.
- Butcher, L. M., Kennedy, J. K., & Plomin, R. (2006). Generalist genes and cognitive neuroscience. Current Opinion in Neurobiology, 16(2), 145–151. CrossRef
- Heaton, R. K., Baade, L. E., & Johnson, K. L. (1978). Neuropsychological test results associated with psychiatric disorders in adults. Psychological Bulletin, 85, 141–162. CrossRef
- Johnstone, E. C., Crow, T. J., Frith, C. D., Husband, J., & Kreel, L. (1976). Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet, 2, 924–926. CrossRef
- Sabb, F. W., Bearden, C. E., Glahn, D. C., Parker, D. S., Freimer, N., & Bilder, R. M. (2008). A collaborative knowledge base for cognitive phenomics. Molecular Psychiatry, 13(4), 350–360. CrossRef
- Sabb, F. W., Burggren, A. C., Higier, R., Fox, J., He, J., Parker, D. S., et al. (2009). Challenges in phenotype definition in the whole-genome era: genetic influences on memory and Intelligence in the healthy population. Neuroscience.
- The International Schizophrenia Consortium (2009). Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature, 460, 748–752.
- The Neuropsychology of Schizophrenia Circa 2009
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Volume 19, Issue 3 , pp 277-279
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- Springer US
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- Cognitive neuroscience
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- Robert M. Bilder (1)
- Author Affiliations
- 1. Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, Department of Psychology, College of Letters and Science, and Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, CA, USA