, Volume 19, Issue 3, pp 277-279,
Open Access This content is freely available online to anyone, anywhere at any time.

The Neuropsychology of Schizophrenia Circa 2009

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The last 30 years have been marked by the emergence of transformative technologies for the study of brain structure-function relations, and these have been deployed vigorously to help unravel the mysterious causes for, and treatments for the schizophrenia syndrome. Despite the progress, the ultimate goal—to identify a “smoking gun,” in the form of a cognitive, a functional anatomical or a genetic signature responsible for the brain pathology underlying schizophrenia—remains elusive. This collection of articles from global leaders in neuropsychological research on schizophrenia makes poignant how much our thinking has changed over the last three decades, but also that we still have more questions than answers about the fundamental neurobiological underpinnings of schizophrenia.

To put the progress in perspective, we may recall the conclusions of Heaton et al. (1978), following their incisive review of neuropsychological studies of psychiatric disorders:

“The finding that chronic or proces