Neurochemical Research

, Volume 40, Issue 2, pp 301–307

Advances in Astrocyte-targeted Approaches for Stroke Therapy: An Emerging Role for Mitochondria and microRNAS

Overview

DOI: 10.1007/s11064-014-1373-4

Cite this article as:
Stary, C.M. & Giffard, R.G. Neurochem Res (2015) 40: 301. doi:10.1007/s11064-014-1373-4

Abstract

Astrocytes are critical regulators of neuronal function and an effective target for stroke therapy in animal models. Identifying individual targets with the potential for simultaneous activation of multiple downstream pathways that regulate astrocyte homeostasis may be a necessary element for successful clinical translation. Mitochondria and microRNAs each represent individual targets with multi-modal therapeutic potential. Mitochondria regulate metabolism and apoptosis, while microRNAs have the capacity to bind and inhibit numerous mRNAs. By combining strategies targeted at maintaining astrocyte function during and following cerebral ischemia, a synergistic therapeutic effect may be achieved.

Keywords

Cerebral ischemiamiRMetabolismChaperonesATPNeuron

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of AnesthesiaStanford University School of MedicineStanfordUSA