Neurochemical Research

, Volume 38, Issue 4, pp 780–788

Capparis ovata Modulates Brain Oxidative Toxicity and Epileptic Seizures in Pentylentetrazol-Induced Epileptic Rats

Authors

    • Neuroscience Research Center, Medical FacultySuleyman Demirel University
    • Department of Biophysics, Medical FacultySuleyman Demirel University
  • Mehmet Berk Akay
    • Medical FacultySuleyman Demirel University
  • Ömer Çelik
    • Neuroscience Research Center, Medical FacultySuleyman Demirel University
    • Department of Biophysics, Medical FacultySuleyman Demirel University
  • Muhammed İkbal Yıldırım
    • Medical FacultySuleyman Demirel University
  • Erdinç Balcı
    • Medical FacultySuleyman Demirel University
  • Vedat Ali Yürekli
    • Department of Neurology, Medical FacultySuleyman Demirel University
Original Paper

DOI: 10.1007/s11064-013-0978-3

Cite this article as:
Nazıroğlu, M., Akay, M.B., Çelik, Ö. et al. Neurochem Res (2013) 38: 780. doi:10.1007/s11064-013-0978-3

Abstract

It has been widely suggested that oxidative stress products play an important role in the pathophysiology of epilepsy. Capparis ovata (C. ovata) may useful treatment of epilepsy because it contains antioxidant flavonoids. The current study was designed to determine the effects of C. ovata on lipid peroxidation, antioxidant levels and electroencephalography (EEG) records in pentylentetrazol (PTZ)-induced epileptic rats. Thirty-two rats were randomly divided into four groups. First group was used as control although second group was PTZ group. Oral 100 and 200 mg/kg C. ovata were given to rats constituting the third and fourth groups for 7 days before PTZ administration. Second, third and forth groups received 60 mg/kg PTZ for induction of epilepsy. Three hours after administration of PTZ, EEG records, brain cortex and blood samples were taken all groups. The lipid peroxidation levels of the brain cortex, number of spikes and epileptiform discharges of EEG were higher in PTZ group than in control and C. ovata group whereas they were decreased by C. ovata administration. Vitamin A, vitamin C, vitamin E and β-carotene concentrations of brain cortex and latency to first spike of EEG were decreased by the PTZ administration although the brain cortex and plasma vitamin concentrations, and brain cortex and erythrocyte glutathione and glutathione peroxidase values were increased in PTZ + 100 and PTZ + 200 mg C. ovata groups. In conclusion, C. ovata administration caused protection against the PTZ-induced brain oxidative toxicity by inhibiting free radical and epileptic seizures, and supporting antioxidant redox system.

Keywords

C. ovataEpilepsyAntioxidantSeizuresOxidative stressVitamin E

List of Abbreviations

GSH

Glutathione

GSH-Px

Glutathione peroxidase

MDA

Malondialdehyde

NO

Nitric oxide

PTZ

Pentylentetrazol

ROS

Reactive oxygen species

SOD

Superoxide dismutase

EEG

Electroencephalography

Copyright information

© Springer Science+Business Media New York 2013