Neurochemical Research

, Volume 36, Issue 10, pp 1939–1944

Decreased Expression of Lysosomal Alpha-Galactosiase A Gene in Sporadic Parkinson’s Disease

Authors

  • Guanghua Wu
    • Division of Cardiac SurgeryJining Medical College Affiliated Hospital, Jining Medical College
    • Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and TreatmentJining Medical College Affiliated Hospital, Jining Medical College
  • Jian Huang
    • Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and TreatmentJining Medical College Affiliated Hospital, Jining Medical College
  • Xungang Feng
    • Division of NeurologyJining Medical College Affiliated Hospital, Jining Medical College
  • Aimei Zhang
    • Division of NeurologyJining Medical College Affiliated Hospital, Jining Medical College
  • Jifeng Li
    • Division of NeurologyJining Medical College Affiliated Hospital, Jining Medical College
  • Shuchao Pang
    • Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and TreatmentJining Medical College Affiliated Hospital, Jining Medical College
  • Kejin Gu
    • Division of NeurologyJining Medical College Affiliated Hospital, Jining Medical College
  • Haixin Dong
    • Division of Experimental MedicineJining Medical College Affiliated Hospital, Jining Medical College
  • Junping Zhang
    • Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and TreatmentJining Medical College Affiliated Hospital, Jining Medical College
  • Huijie Gao
    • Department of ImmunologyJining Medical College
    • Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and TreatmentJining Medical College Affiliated Hospital, Jining Medical College
Original Paper

DOI: 10.1007/s11064-011-0516-0

Cite this article as:
Wu, G., Huang, J., Feng, X. et al. Neurochem Res (2011) 36: 1939. doi:10.1007/s11064-011-0516-0

Abstract

Parkinson’s disease (PD) is a progressive neurodegenerative disease. To date, the causal genes and variants associated with sporadic PD are largely unknown. Accumulating evidence demonstrates that autophagy delivers alpha-syncuclein proteins to lysosome for degradation and dysfunctional autophagy is involved in the PD pathogenesis. We have previously screened a group of lysosomal hydrolases and found that alpha-galactosidase A (GLA) activity is significantly decreased in the peripheral leukocytes of sporadic PD patients. In this study, GLA transcript and protein levels were semi-quantitatively examined. The GLA transcript (P = 0.020) and protein (P = 0.027) levels in the peripheral leukocytes of sporadic PD patients were significantly decreased, compared to age- and sex-matched healthy controls. Furthermore, decreased GLA gene expression levels were strongly associated with sporadic PD (OR 3.33, 95%CI 1.17–9.52, P = 0.024). Therefore, our data suggest that insufficient GLA activity may contribute to the pathogenesis of sporadic PD. The underlying molecular mechanisms remain to be determined.

Keywords

Parkinson’s diseaseLysosomeAlpha-galactosidase AGene expressionLeukocytes

Copyright information

© Springer Science+Business Media, LLC 2011