Neurochemical Research

, Volume 36, Issue 6, pp 1037–1045

Comparison of Glucocorticoid Receptor and Ionized Calcium-Binding Adapter Molecule 1 Immunoreactivity in the Adult and Aged Gerbil Hippocampus Following Repeated Restraint Stress

  • Joon Ha Park
  • Ki-Yeon Yoo
  • Choong Hyun Lee
  • In Hye Kim
  • Bich Na Shin
  • Jung Hoon Choi
  • Jeong Ho Park
  • In Koo Hwang
  • Moo-Ho Won
Original Paper

DOI: 10.1007/s11064-011-0444-z

Cite this article as:
Park, J.H., Yoo, KY., Lee, C.H. et al. Neurochem Res (2011) 36: 1037. doi:10.1007/s11064-011-0444-z
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Abstract

Stress leads to changes in homeostasis and internal balance of the body and is known to be one of important factors in the development of several diseases. In the present study, we investigated changes in glucocorticoid receptor (GR) and ionized calcium-binding adapter molecule 1 (Iba-1) immunoreactivity in the adult and aged gerbil hippocampus after chronic restraint stress. Serum corticosterone level was much higher in both the stress-groups than the control groups. No neuronal death was found in all hippocampal subregions of the adult and aged gerbil after chronic restraint stress. GR immunoreactivity was decreased in both the adult and aged groups after repeated restraint stress; however, GR immunoreactivity in the adult-stress-group was decreased much more than that in the aged-stress-group. Iba-1 immunoreactive microglia were hypertrophied and activated in the adult group after repeated restraint stress; in the aged-stress-group, there was no any significant change in Iba-1 immunoreactive microglia. In brief, level of GR, not Iba-1, in the hippocampus was much decreased in the adult gerbil compared to the aged gerbil following chronic restraint stress.

Keywords

Chronic restraint stress Corticosterone Glucocorticoid receptor Microglial activation Aging 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Joon Ha Park
    • 1
  • Ki-Yeon Yoo
    • 2
  • Choong Hyun Lee
    • 3
  • In Hye Kim
    • 4
  • Bich Na Shin
    • 4
  • Jung Hoon Choi
    • 5
  • Jeong Ho Park
    • 6
  • In Koo Hwang
    • 7
  • Moo-Ho Won
    • 1
  1. 1.Department of Neurobiology, School of MedicineKangwon National UniversityChuncheonSouth Korea
  2. 2.Department of Oral Anatomy, College of DentistryGangneung-Wonju National UniversityGangneungSouth Korea
  3. 3.Laboratory of Veterinary Pharmacology, College of Veterinary MedicineSeoul National UniversitySeoulSouth Korea
  4. 4.Department of Physiology, College of MedicineHallym UniversityChuncheonSouth Korea
  5. 5.Department of Anatomy, College of Veterinary MedicineKangwon National UniversityChuncheonSouth Korea
  6. 6.Division of Applied Chemistry and BiotechnologyHanbat National UniversityDaejeonSouth Korea
  7. 7.Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary ScienceSeoul National UniversitySeoulSouth Korea

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