Neurochemical Research

, Volume 36, Issue 7, pp 1270–1279

Regulation of Cortical Neuron Migration by the Reelin Signaling Pathway

  • Takao Honda
  • Kazuma Kobayashi
  • Katsuhiko Mikoshiba
  • Kazunori Nakajima
Original Paper

DOI: 10.1007/s11064-011-0407-4

Cite this article as:
Honda, T., Kobayashi, K., Mikoshiba, K. et al. Neurochem Res (2011) 36: 1270. doi:10.1007/s11064-011-0407-4

Abstract

Reeler is a mutant mouse with defects in layered structures of the central nervous system, such as the cerebral cortex, hippocampus, and cerebellum, and has been extensively examined for more than half a century. The full-length cDNA for the responsible gene for reeler, reelin, was serendipitously identified, revealing that Reelin encodes a large secreted protein. So far, two Reelin receptors, apolipoprotein E receptor 2 and very low-density lipoprotein receptor, and the cytoplasmic adaptor protein Disabled homolog 1 (Dab1) have been shown to be essential for Reelin signaling. Although a number of downstream cascades of Dab1 have also been reported using various experimental systems, the physiological functions of Reelin in vivo remain controversial. Here, we review recent advances in the understanding of the Reelin-Dab1 signaling pathway in the developing cerebral cortex.

Keywords

ReelerReelinDab1ApoER2VLDLR

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Takao Honda
    • 1
  • Kazuma Kobayashi
    • 1
  • Katsuhiko Mikoshiba
    • 2
  • Kazunori Nakajima
    • 1
  1. 1.Department of AnatomyKeio University School of MedicineShinjuku-ku, TokyoJapan
  2. 2.Laboratory for Developmental NeurobiologyRIKEN Brain Science InstituteWako, SaitamaJapan