Neurochemical Research

, Volume 36, Issue 5, pp 761–765

Effect of Oral Resveratrol on the BDNF Gene Expression in the Hippocampus of the Rat Brain

  • Mostafa Rahvar
  • Mohsen Nikseresht
  • Sayed Mohammad Shafiee
  • Fakhraddin Naghibalhossaini
  • Mozhgan Rasti
  • Mohammad Reza Panjehshahin
  • Ali Akbar Owji
Original Paper

DOI: 10.1007/s11064-010-0396-8

Cite this article as:
Rahvar, M., Nikseresht, M., Shafiee, S.M. et al. Neurochem Res (2011) 36: 761. doi:10.1007/s11064-010-0396-8

Abstract

Resveratrol is a plant polyphenolic compound. Evidence indicates that resveratrol has beneficial effects against aging and neurodegenerative diseases. The goal of our study was in vivo examination of the effects of resveratrol on the abundance of mRNA encoding Brain Derived Neurotrophic Factor (BDNF) in the hippocampus of rat brain. Rats were administrated orally by different doses (2.5–20 mg/kg bwt) of resveratrol for 3, 10 and 30 days. Saline was used as control and 10% ethanol in saline was used as vehicle for resveratrol. Measurement of BDNF mRNA by Real-time RT–PCR showed that levels of the mRNA for BDNF were significantly and dose dependently elevated in the hippocampal tissues of rats. The findings suggest that the neuroprotective effects of resveratrol may be at least partly due to its inducing effects on the expression levels of the BDNF mRNA.

Keywords

Resveratrol BDNF Hippocampus Rat 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Mostafa Rahvar
    • 1
  • Mohsen Nikseresht
    • 2
  • Sayed Mohammad Shafiee
    • 1
  • Fakhraddin Naghibalhossaini
    • 1
  • Mozhgan Rasti
    • 1
  • Mohammad Reza Panjehshahin
    • 3
  • Ali Akbar Owji
    • 1
  1. 1.Department of BiochemistryShiraz University of Medical SciencesShirazIran
  2. 2.Department of BiochemistryYasuj University of Medical SciencesYasujIran
  3. 3.Department of Medicinal and Natural Products Chemistry Research CenterShiraz University of Medical SciencesShirazIran

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