Neurochemical Research

, Volume 35, Issue 10, pp 1530–1537

The Role of Oxidative Stress in Amyotrophic Lateral Sclerosis and Parkinson’s Disease

Authors

    • Neurology DepartmentHôpital A. Michallon
    • Grenoble UniversityHôpital A. Michallon
  • Vanessa Chanteperdrix
    • Biology DepartmentHôpital A Michallon
  • Candice Trocmé
    • Laboratory of Enzymology/DBPCCHU Hôpital Michallon
  • Pierre Casez
    • Medical Information UnitA. Michallon
  • Catherine Garrel
    • Biology DepartmentHôpital A Michallon
  • Gérard Besson
    • Neurology DepartmentHôpital A. Michallon
ORIGINAL PAPER

DOI: 10.1007/s11064-010-0212-5

Cite this article as:
Baillet, A., Chanteperdrix, V., Trocmé, C. et al. Neurochem Res (2010) 35: 1530. doi:10.1007/s11064-010-0212-5

Abstract

We examined oxidative stress markers of 31 patients suffering from ALS, 24 patients suffering from PD and 30 healthy subjects were included. We determined the plasma levels of lipid peroxidation (malondialdehyde, MDA), of protein oxidative lesions (plasma glutathione, carbonyls and thiols) and the activity of antioxidant enzymes i.e. erythrocyte Cu,Zn-Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px) and catalase. MDA and thiols were significantly different in both neurodegenerative diseases versus control population. A trend for an enhancement of oxidized glutathione was noted in ALS patients. Univariate analysis showed that SOD activity was significantly decreased in ALS and GSH-Px activity was decreased in PD. After adjusting for demographic parameters and enzyme cofactors, we could emphasize a compensatory increase of SOD activity in PD. Different antioxidant systems were not involved in the same way in ALS and PD, suggesting that oxidative stress may be a cause rather than a consequence of the neuronal death.

Keywords

Oxidative stressReactive oxygen speciesNeurodegenerationTrace elementAmyotrophic lateral sclerosisParkinson’s diseaseGlutathione peroxidaseSuperoxide dismutase

Abbreviations

ALS

Amyotrophic lateral sclerosis

EDTA

Ethylenediaminetetraacetic acid

GSH-Px

Glutathione peroxidase

MDA

Malondialdehyde

MOPS

3-N-morpholinopropaneslfonic acid

PD

Parkinson’s disease

SOD

Cu,Zn-Superoxide dismutase

Copyright information

© Springer Science+Business Media, LLC 2010