Neurochemical Research

, Volume 35, Issue 9, pp 1295–1301

Role of oxidative stress in the pathophysiology of bipolar disorder

  • Amanda V. Steckert
  • Samira S. Valvassori
  • Morgana Moretti
  • Felipe Dal-Pizzol
  • João Quevedo
Overview

DOI: 10.1007/s11064-010-0195-2

Cite this article as:
Steckert, A.V., Valvassori, S.S., Moretti, M. et al. Neurochem Res (2010) 35: 1295. doi:10.1007/s11064-010-0195-2

Abstract

In this work, we review the studies of oxidative stress markers, showing association with the pathophysiology of bipolar disorder (BD). BD is a prevalent, chronic and highly disabling psychiatric disorder. Several hypotheses have been postulated to explain the exact neurochemical mechanisms underlying the pathophysiology of BD, including a role for monoamines, gamma-amino butyric acid (GABA), glutamate, and second messenger singling pathways. More recently, oxidative stress has been implicated in the pathogenesis of BD. Recent studies have reported increased products of lipid peroxidation and alterations of the major antioxidants enzymes in patients with BD. It has been widely demonstrated that the generation of reactive oxygen species (ROS) plays a critical role in the pathophysiology of several neuropsychiatric disorders, such BD.

Keywords

Free radicals Antioxidant enzymes Bipolar disorder Oxidative stress 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Amanda V. Steckert
    • 1
    • 2
  • Samira S. Valvassori
    • 1
  • Morgana Moretti
    • 1
  • Felipe Dal-Pizzol
    • 2
  • João Quevedo
    • 1
    • 3
  1. 1.Laboratory of Neurosciences and National Institute for Translational Medicine, Postgraduate Program in Health Sciences, Health Sciences UnitUniversity of Southern Santa CatarinaCriciúmaBrazil
  2. 2.Laboratory of Experimental Pathophysiology and National Institute for Translational Medicine, Postgraduate Program in Health Sciences, Health Sciences UnitUniversity of Southern Santa CatarinaCriciúmaBrazil
  3. 3.Laboratório de NeurociênciasUniversidade do Extremo Sul CatarinenseCriciúmaBrazil

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