Neurochemical Research

, Volume 35, Issue 5, pp 830–834

Increased Plasma Levels of Brain Derived Neurotrophic Factor (BDNF) in Patients with Fibromyalgia

  • Lisete Haas
  • Luis V. C. Portela
  • Ana Elisa Böhmer
  • Jean Pierre Oses
  • Diogo R. Lara
Original Research

DOI: 10.1007/s11064-010-0129-z

Cite this article as:
Haas, L., Portela, L.V.C., Böhmer, A.E. et al. Neurochem Res (2010) 35: 830. doi:10.1007/s11064-010-0129-z

Abstract

Brain-derived neurotrophic factor (BDNF) is involved in neuronal survival and synaptic plasticity of the central and peripheral nervous system. BDNF appears to modulate nociceptive sensory inputs and pain hypersensitivity and has been studied in pathological situations, including chronic pain conditions and major depression. Increased serum BDNF levels have been recently reported in fibromyalgia (FM). In the present study, we assessed plasma BDNF levels in patients with FM and controls. Plasma BDNF was measured from 30 female patients with FM and 30 healthy age- and gender-matched volunteers using an enzyme immunoassay. FM patients showed higher levels of BDNF (FM = 167.1 ± 171.2 pg/mL) when compared with the control group (control = 113.8 ± 149.6 pg/mL) (P = 0.049; Mann–Whitney test). Six out of 30 controls presented superior values to the medium (15/15) of the patients with fibromyalgia (129 pg/mL) (P = 0.029, Fisher exact test). There was no correlation between plasma BDNF levels and age, disease duration, pain score, number of pain points and HAM-D score. Our results confirm previous findings of increased plasma BDNF levels in patients with FM, suggesting that BDNF may be involved in the pathophysiology of Fibromyalgia, despite high levels of depression.

Keywords

BDNFFibromyalgiaPainDepressionAntidepressant

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Lisete Haas
    • 1
  • Luis V. C. Portela
    • 2
  • Ana Elisa Böhmer
    • 2
  • Jean Pierre Oses
    • 3
  • Diogo R. Lara
    • 1
  1. 1.Departamento de Ciências Fisiológicas, Faculdade de BiociênciasPontifícia Universidade Católica do Rio Grande do SulPorto AlegreBrazil
  2. 2.Departamento de Bioquímica, ICBSUFRGSPorto AlegreBrazil
  3. 3.Universidade Católica de PelotasPelotasBrazil